Currently, filtration surgery has been considered as the most effective therapy for glaucoma; however, the scar formation in the surgical area may often lead to failure to the procedure. An implanted drug delivery system may provide localized and sustained release of a drug over an extended period. Poly (ethylene glycol)-poly (ε-caprolactone)-poly (ethylene glycol) (PEG-PCL-PEG, PECE) hydrogel ...

PURPOSE To study the effect of acute or chronic intracameral injection of hyaluronic acid on intraocular pressure (IOP) in rats. METHODS Acute or chronic injections of hyaluronic acid were performed unilaterally in the rat eye's anterior chamber, whereas the contralateral eye was injected with saline solution. IOP was assessed daily or weekly by a tonometer in conscious rats. IOP was also ass...

PURPOSE To analyze the outcomes of post-cataract surgery descemetopexy for Descemet membrane detachment using intracameral air injection. SETTING Cornea Department, LV Prasad Eye Institute, Hyderabad, India. DESIGN Interventional case series. METHODS The clinical data of patients who had descemetopexy from August 2010 to February 2011 for Descemet membrane detachment after cataract surger...

The effects of intracameral injection of hydrogen peroxide were examined using different techniques in young (4 to 6 weeks of age, =500 g) and adult (3 to 6 months of age, 2.5 to 3.5 kg) rabbits. A response occurred that included changes in intraocular pressure, increased permeability of the iris vasculature, and swelling of the ciliary processes. The initial fall in intraocular pressure was th...

Adeno-associated viruses (AAVs) are used extensively as a gene delivery vehicle for retinal gene therapy, yet its ability to target the anterior segment of the eye, critical to unlocking therapeutic opportunities, is less characterized. Previously, self-complimentary (sc) AAV was shown to be necessary for transduction of the cornea and trabecular meshwork (TM), limiting the size of the gene tra...

BACKGROUND The anterior chamber has been shown by pharmacokinetic studies to represent a sanctuary never achieving a tumoricidal dose with the present administration routes, such as systemic, intra-arterial, or intravitreal injections. METHOD A novel intracameral chemotherapy technique is described to control aqueous seeding in a pilot unilateral group E retinoblastoma case with primary aqueo...

PURPOSE To report cases of intraocular inflammation after intracameral injection of a very high dose of cefuroxime at the end of uneventful cataract surgery. SETTING Department of Ophthalmology, Bordeaux University Hospital, Bordeaux, France. DESIGN Case series. METHODS Patients were followed on an outpatient basis and were examined postoperatively at 1 and 5 days and 6 weeks. Central mac...

PURPOSE The purpose of this study is to assess the efficacy and safety of intracameral mydriatic solution, as compared to preoperative topical mydriatics, in patients undergoing manual small incision cataract surgery (MSICS) under peribulbar anesthesia. To assess the sustainability of intracameral mydriasis in MSICS by monitoring pupil size at specific junctures during the surgery. METHODS Th...

Purpose. To evaluate the safety and efficacy of intracameral vancomycin during cataract surgery using a standardized dosage and delivery technique. Methods. The charts of 20,719 consecutive eyes that underwent phacoemulsification with intraocular lens implantation in a single ambulatory surgery center were retrospectively reviewed over a 5-year period. Results. The first 11,333 consecutive case...