Norlin, Andreas, and Hans G. Folkesson. Ca2 -dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs. Am J Physiol Lung Cell Mol Physiol 282: L642–L649, 2002; 10.1152/ajplung.00417.2000.—We investigated the importance of changes in intracellular Ca2 concentration ([Ca2 ]i) for amiloride-sensitive alveolar fluid clearance (AFC) in late-gestational guinea pigs. Fetal guin...

In mammals, the brain contains four distinct fluid compartments: the blood in the cerebral vasculature, the cerebrospinal fluid (CSF) in the ventricular system and subarachnoid space, the interstitial fluid that bathes cells of the brain parenchyma, and the intracellular fluid contained within neurons and glia. These four fluid compartments, each with their own unique volume and solute composit...

Mechanical signals are important regulators of skeletal homeostasis, and strain-induced oscillatory fluid flow is a potent mechanical stimulus. Although the mechanisms by which osteoblasts and osteocytes respond to fluid flow are being elucidated, little is known about the mechanisms by which bone marrow-derived mesenchymal stem cells respond to such stimuli. Here we show that the intracellular...

The brain renin-angiotensin system is implicated in the regulation of blood pressure (BP) and fluid homeostasis. Recent studies reveal that 2 forms of renin are expressed in the brain of rodents and humans: secreted prorenin and a nonsecreted intracellular form of active renin (icREN). Although the intracellular action of renin has long been postulated, no data supporting its role in BP regulat...

OBJECTIVE The purpose of this paper is to investigate the fluid status of patients in the early stages of continuous ambulatory peritoneal dialysis (CAPD). PATIENTS AND METHODS A total of 36 patients (13 males and 23 females), hospitalized in the Nephrology CAPD Center, Peking University Third Hospital, and undergoing intubation and CAPD treatment, were recruited in this study. By utilize a b...

Ko, S. B. H., S. Naruse, M. Kitagawa, H. Ishiguro, M. Murakami, and T. Hayakawa. Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G48–G54, 1999.—The effects of arginine vasopressin (AVP) on pancreatic ductal secretion were studied in guinea pigs. In the isolated vascularly perfused pancreas, AVP reduced sec...

OBJECTIVE To explore the functional role of vacuolar H(+)-ATPase in the pH regulation of epididymal fluid and its effect on sperm motility. DESIGN Experimental study. SETTING Physiology laboratory in a university. ANIMAL(S) Immature male Sprague-Dawley rats. INTERVENTION(S) The H(+)-ATPase inhibitor was applied to the primary culture of epididymal cells. MAIN OUTCOME MEASURE(S) The in...

The effect of lipid composition on the intracellular antibacterial activity of ampicillin-containing liposomes was studied in vitro by using mouse peritoneal macrophages infected with Listeria monocytogenes. Two types of liposomes, a fluid type, consisting of cholesterol-phosphatidylcholine-phosphatidylserine (5:4:1), and a solid type, consisting of cholesterol-distearoylphosphatidylcholine-dip...