Introduction: ICP is a reversible rare disorder prevailing in 2% of pregnancies resulting debilitating feto-maternal consequences. Maternal problems resolves soon after delivery but fetal complications result multiple deteriorations. Present study was undertaken to assess the pregnancy outcomes with on both mother and fetus. Methodology: A prospective design used conducted tertiary health care ...

Multiple studies have been conducted to demonstrate the role of viruses in causing biliary atresia. Although cytomegalovirus (CMV) is known to cause intrahepatic bile duct destruction, its role in biliary atresia is not proven. We report two cases of CMV infection, initially presenting with intrahepatic cholestasis, who subsequently developed biliary atresia.

(Abstracted from Lancet Gastroenterol Hepatol 2021;6:547–558) Ursodeoxycholic acid (UA) is a common treatment for intrahepatic cholestasis of pregnancy (ICP), and its use supported by the Society Maternal-Fetal Medicine. However, evidence benefit UA to fetal neonatal outcomes in this patient population unclear.

Hitherto little attention has been paid to cholestatic jaundice in the newborn which occurs in the absence of rhesus incompatibility. 4 such cases, among a consecutive series of 24 newborns with prolonged neonatal jaundice occurring in the Devon and Exeter clinical area since 1960, are here described in detail to demonstrate that their clinical and histological picture, and their prognosis, is ...

Thus, the changes in maternal steroid metabolism caused by cholestasis are reflected in the steroid profile of the fetoplacental circulation. Furthermore, maternal intrahepatic cholestasis may result in the production of some substance which crosses the placenta and affects fetal steroid metabolism. Received for publication 7 November 1973 and in revised form 13 February 1974. INTRODUCTION Intr...

elevated serum level of bilirubin is a common manifestation which is occurred in several diseases. hyperbilirubinemia can manifest either conjugated or unconjugated. conjugated or direct hyperbilirubinemia usually are caused by hepatocellular diseases or cholestatic liver diseases. merely conjugated hyperbilirubinemia is the main manifestation of two congenital syndromes, including dubin-johnso...