Anesthetized dogs were cooled to a core body temperature of 26 degree C. or maintained at a body temperature of 37 degree C. during periods of 5 and 10 hours of LAD coronary artery occlusion. Subsequent macroscopic dehydrogenase enzyme mapping showed that ischemic injury was 25 per cent less after 5 hours of coronary occlusion and 20 per cent less after 10 hours of occlusion in hypothermic dogs...

High-dose lead exposure in rodents has been shown to produce pathognomonic lead intranuclear inclusion bodies and to result in an increased incidence of renal adenocarcinomas. Studies from this laboratory and others have demonstrated the presence of high-affinity renal lead-binding proteins in rat kidneys which act as tissue sinks for lead at low dose levels. Cell-free nuclear translocation stu...

Optineurin (OPTN) is a multifunctional protein involved in cellular morphogenesis, vesicle trafficking, maintenance of the Golgi complex, and transcription activation through its interactions with the Rab8, myosin 6 (MYO6), huntingtin. Recently, OPTN immunoreactivity has been reported in intranuclear inclusions in patients with neuronal intranuclear inclusions disease (NIID). Other studies have...

Many authors have written about intranuclear inclusion bodies ; their presence has usually been linked with known virus infection, and their association with tumors has been less frequently reported. Intranuclear inclusions have been described, however, by Luck6 (1) in adenocarcinoma of the frog’s kidney. Russell ( 2 ) , and Wolf and Orton (3 ) have reported inclusion bodies in nuclei of the ce...

Ex vivo, human mesenchymal stem cells (hMSCs) undergo spontaneous cellular senescence after a limited number of cell divisions. Intranuclear structures of the nuclear lamina were formed in senescent hMSCs, which are identified by the presence of Hayflick-senescence-associated factors. Notably, spatial changes in lamina shape were observed before the Hayflick senescence-associated factors, sugge...

BACKGROUND Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by progressive ptosis, dysphagia and proximal limb weakness. The autosomal dominant form of this disease is caused by short expansions of a (GCG)6 repeat to (GCG) in the PABPN1 gene. The mutations lead to the expansion of a polyalanine stretch from 10 to 12-17 alanines in the N-terminus of PABPN1. The ...

PURPOSE The aim of this study was to evaluate masticatory efficiency in children with normal primary occlusion and malocclusion and to correlate efficiency with body variables. METHODS Thirty children were divided into three groups: Group I with normal occlusion (n = 10), Group II with posterior crossbite (n = 10) and Group III with anterior open bite (n = 10). They chewed standardized silico...

A brain biopsy was examined from a 7 year old boy with subacute sclerosing panencephalitis. Intranuclear deposits of measles antigens were demonstrated in parenchymal cells by immunofluorescence. Electron microscopy showed viral nucleocapsids in nucleoliform inclusions and unusual rod-like intranuclear structures which resemble structures previously described only in tissue cultures infected wi...