Abstract Corneal neovascularization (CNV) causes higher-order aberrations, corneal edema, ocular inflammation, and transplant rejection, thereby decreasing visual acuity. In this study, we investigated the effects of topical administration kappa opioid receptor agonist nalfurafine (TRK-820) on CNV. To induce CNV, intrastromal sutures were placed stroma BALB/c mice for 2 weeks. Nalfurafine (0.1 ...

I ntrastromal corneal rings and ring segments work in accordance with the postulates of Barraquer and Blavatskaya, which state that an addition in the periphery of the cornea will result in its flattening. The thickness and diameter of the implant determine how much the cornea will be flattened. That is, the more tissue that is added (ie, ring thickness) and the smaller its diameter, the greate...

This paper provides images and a description of an unusual manifestation of relapsing polychondritis presenting initially with isolated ocular signs, mimicking infective keratitis. We present an interventional case report of a 75-year-old man who presented with marked left ocular irritation and photophobia. Ophthalmological examination disclosed corneal intrastromal infiltrate and hypopyon whic...

PURPOSE Intrastromal injection of mice with antigens from the parasitic helminth that causes river blindness (Onchocerca volvulus) induces eosinophil recruitment to the corneal stroma at the time of maximum corneal opacification and neovascularization. The present study was conducted to examine the role of eosinophils and neutrophils in onchocercal keratitis in control C57Bl/6 mice and in inter...

PURPOSE To produce animal models of Acanthamoeba keratitis and to evaluate the advantages and adaptation range of each of the three methods employed. MATERIALS AND METHODS Mice and Wistar rats in three groups of 15 rats and 15 mice each were used to establish the models. Right corneas in group A were scratched and challenged with Acanthamoeba. Those in group B were scratched and covered with ...

PURPOSE To determine the main causes of intrastromal corneal ring segment (ICRS) explantation and the relationship with the microscopic findings on the ICRS surface. SETTING Vissum Corporation-Instituto Oftalmológico de Alicante, Alicante, Spain. METHODS This study evaluated ICRS that were explanted in centers in Spain from 2000 to 2008. Clinical data (reasons for explantation, date of impl...

AIM To evaluate the clinical outcomes after Ferrara intrastromal corneal ring segments (ICRS) reoperation in patients with keratoconus. METHODS A total of 37 keratoconus eyes implanted with intrastromal corneal ring segments, which had an ICRS exchange, addition, reposition or removal were evaluated. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), keratometry (K), asphe...