We describe a patient with fever, pancytopenia, and hepato-splenomegaly associated with the finding of neoplastic lymphoid cells and histiocytes with hemophagocytosis in the peripheral smear; the diagnostic features were suggestive for a biological overlap between a large B-cell lymphoma with intravascular involvement and the Asian variant of intravascular B-cell lymphoma.

Intravascular large B-cell lymphoma is an extremely rare extranodal lymphoma that proliferates in the lumen of the blood vessels while sparing the organ parenchyma. It usually presents with CNS and skin involvement. A 65-year-old Caucasian female presented with fevers and chills of 3-4 months' duration. Bone marrow biopsy done 3 months prior showed no significant myelodysplasia or lymphoid aggr...

Intravascular large B-cell lymphoma (IVLBL) is a rare subtype of diffuse large B-cell lymphoma that resides in the lumen of blood vessels. Patients typically present with nonspecific findings, particularly bizarre neurologic symptoms, fever, and skin lesions. A woman presented with shortness of breath and a chest CT scan showed diffuse interstitial thickening and ground glass opacities suggesti...

A 77-year-old woman was referred with renal impairment—serum creatinine 230 mmol/L (2.61 mg/dL) and proteinuria 2.14 g/day. The past medical history included hypertension, sicca symptoms and osteoarthritis. Her medications included amlodipine 5 mg od, omeprazole 20 mg od and prednisolone 10 mg od. Systematic enquiry revealed lethargy and 6 kg weight loss over 6 months. Examination was unremarka...

Intravascular lymphoma (IVL) is a rare type of extra-nodal lymphoma with an aggressive clinical course characterized by proliferation of large lymphoma cells within the lumina of small vessels. Diagnosis of IVL is extremely difficult because of its varied clinical symptoms and the absence of lymphadenopathy, which requires histological confirmation. We report a case of a patient with Mono-Neuri...

Intravascular lymphoma is a very rare form of large B-cell non-Hodgkin's lymphoma which is characterized by selective growth of lymphoma cells within the lumina of small blood vessels. We report a 64-year-old woman visited hospital because of persistent cough, intermittent high fever as high as 38.7 °C and occasional shortness of breath. Her chest CT showed left upper lobe pneumonia and tubercu...

A 55-year-old man presented with flaccid paraparesis. Immunologic and serologic tests were unrevealing. Nuclear magnetic resonance revealed brain and spinal ischemic lesions suggestive of isolated central nervous system vasculitis. Treatment with cyclophosphamide and steroids was initiated, resulting in clinical improvement. However, 1 month later, the patient acutely developed altered mental s...

A 59-year-old man presented with acalculous cholecystitis and hepatomegaly. Routine laboratory tests were remarkable for thrombocytopenia (125 109/L), alanine aminotransferase 95 U/L, aspartate aminotransferase 760 U/L, alkaline phosphatase 223 U/L, and lactate dehydrogenase 3755 U/L. A peripheral smear showed morphologically normal red blood cells and large atypical lymphoid cells (panel A and...