A mathematical model of a drug transport after rapid injection is given. It takes into account three processes: drug plasma protein binding in central compartment transport processes between the central compartment and the peripheral compartment elimination of a drug from the central compartment.

Phenytoin has been in use for decades, but healthcare providers should remain alert to potential risks. Analysis of an incident report received through the National System for Incident Reporting (NSIR)* suggests opportunities to enhance system safeguards with this medication when prescribed for intravenous (IV) administration. The hospital where the incident occurred wanted to share the informa...

WARNING Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia and granulocytopenia) are known to occur after the administration of chloramphenicol. In addition, there have been reports of aplastic anemia attributed to chloramphenicol which later terminated in leukemia. Blood dyscrasias have occurred after both short term and prolonged therapy with this drug. ...

Serum and ventricular fluid pharmacokinetic data for amikacin were evaluated prospectively in 10 hydrocephalic children with suspected ventriculitis. After the fourth or fifth intravenous 7.5-mg/kg dose of amikacin given every 8 h, mean peak serum levels were 24.3 +/- 3.2 microgram/ml (achieved at 0.5 h) with a calculated half-life of 2.2 +/- 1.1 h. Mean peak ventricular fluid levels in five pa...

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Purpose To report a case of bilateral acute anterior uveitis in an adult female occurring following the administration of intravenous immunoglobulin (IVIG). Observations A 44-year-old female patient was commenced on IVIG following presentation to hospital with upper limb neuropathic pain. Within two days, she developed bilateral red, painful photophobic eyes. Examination revealed bilateral ac...

Currently, in many centres, intravenous administration of iron is becoming increasingly popular because of higher efficacy and decreased side effects, mainly gastrointestinal, compared with oral iron therapy. Studies of intravenous ferric carboxymaltose administration in the postpartum setting and in patients with non-dialysis-dependent chronic kidney disease revealed a decrease in serum phosph...

Current practices of intravenous lignocaine administration may result in a significant drop in blood level between the peak serum level from the initial bolus and the subsequent steady state from the constant infusion. This can cause a significant interval when plasma lignocaine levels are less than therapeutic, and ventricular ectopy may occur. To eliminate this subtherapeutic interval, a new ...

The child presented to us on day 2 of life with complaints of bilious vomiting. An abdominal X-ray showed a double-bubble sign and a diagnosis of duodenal atresia was made. Duodenodoudenostomy with a feeding jejunostomy using an infant feeding tube was done. Post operatively, breast milk was accidentally connected to the intravenous cannula instead of the jejunostomy tube on day 5 and the baby ...

A thermal aerosol generation process is capable of delivering pure drug reliably to the alveoli where it is absorbed systemically. Although deep lung absorption of drugs administered as an aerosol has been shown to be rapid, detailed characterization of their absorption and distribution has not been reported. The present study describes the pharmacokinetics of prochlorperazine from the moment o...