A new in vitro pharmacokinetic/pharmacodynamic simulator for bacterial biofilms utilizing flow cell technology and confocal laser scanning microscopy is described. The device has the ability to simulate the changing antibiotic concentrations in humans associated with intravenous dosing on bacterial biofilms grown under continuous culture conditions. The free drug concentrations of a single 2-g ...

BACKGROUND It is generally accepted that dialysis may lower plasma osmolality at a faster rate than changes in ocular osmolality. This osmotic difference causes water to migrate from the plasma into the aqueous humor, increasing intraocular pressure. Certain authors have described IOP increase in patients with narrow angles. CASE PRESENTATION Here we report a neovascular glaucoma patient who ...

Clinicians of all specialties need to be aware of a recent, nationwide increase in the number of Actinomyces bloodstream infections. We report a case of bimicrobial bloodstream infection with Actinomyces odontolyticus and Escherichia coli in an intravenous drug user. A 36-year-old, male intravenous drug user was admitted with acute-onset pleuritic chest pain, back pain, pyrexia, tachycardia, ta...

PURPOSE The aim of this study was to use laser Doppler flowmetry to measure anterior choroidal blood flow in the anesthetized rat and to determine the role of nitric oxide (NO) in the maintenance of basal ocular blood flow in vivo. METHODS By using laser Doppler flowmetry, blood flow from the anterior choroid in pentobarbital-anesthetized rats was measured continuously. Graded single doses (0...

Background and Aim: The conventional procedure for removal of porcelain laminate veneers (PLVs) is time-consuming and inconvenient. The purpose of this study was to evaluate the efficacy of Er:YAG laser for debonding of PLVs. Materials and Methods: Forty-eight intact extracted human maxillary anterior teeth received discoid PLVs (24 feldspathic and 24 e-max ceramic). The PLVs had 0.7 mm thickn...

Laser bending is an advanced process in sheet metal forming in which a laser heat source is used to shape the metal sheet. In this paper, temperature distribution in a mild steel sheet metal is investigated numerically and experimentally. Laser heat source is applied through curved paths in square sheet metal parts. Finite element (FE) simulation is performed with the ABAQUS/CAE standard softwa...

Background Recently, the clinical use of low power lasers has increased, and it is said that wound healing is accelerated by their irradiation. The aim of this study was evaluation of the effect of platelet-rich plasma on proliferation and differentiation of human dental pulp stem cells with or without Ga-Al-As laser. Methods: In this experimental study, human lower third molar dental pulp c...

Optical frequency domain imaging (OFDI) using swept laser sources is an emerging second-generation method for optical coherence tomography (OCT). Despite the widespread use of conventional OCT for retinal disease diagnostics, until now imaging the posterior eye segment with OFDI has not been possible. Here we report the development of a highperformance swept laser at 1050 nm and an ophthalmic O...