In a randomised, placebo-controlled clinical trial, anaesthesia was induced with propofol (4 mg/kg) after intravenous premedication with or without midazolam (0.1 mg/kg), in a group of 8 dogs scheduled for ovariohysterectomy. Midazolam administration induced acute behavioural changes, and increased reflex suppression after propofol induction. Compared to the control group, the dose required to ...

conclusions on the basis of our study, we conclude that nasal midazolam spray is acceptable and is a good alternative to oral midazolam as premedication in the pediatric population. objectives to compare the efficacy of midazolam administered orally and by intranasal spray, with the specific objective of assessing their efficacy in terms of acceptability to the patients, whether they achieve a ...

Midazolam is a water soluble 1,4 benzodiazepine which is suitable for intramuscular administration. It is currently used for pre-medication and the induction of anaesthesia. Its antiepileptic properties have been evaluated by studying its effect on interictal spikes on the EEG of six adult epileptic patients. The results indicate that intramuscular midazolam 15 mg is more effective than intramu...

Background: Various drugs, including ketamine and midazolam, are used for sedation in children. Objectives: This study aimed to evaluate the effectiveness of intravenous midazolam combination bone marrow aspiration biopsy children with cancer. Methods: descriptive cross-sectional was conducted on 100 aged six months 17 years candidates or biopsy. Sampling easy, accessible, sequential. Children ...

statement of the problem: some children do not show an appropriate cooperation with their dentist. a number of them cannot be managed by local anesthesia and the usual techniques used to control behaviors, so further steps are required to control their pain and anxiety. pharmaceutical control is recommended through sedation or general anesthesia. purpose: this study was aimed to evaluate two gr...

background: selecting the best medication for upper gi endoscopy in children is a challenging issue. the goal of this study was to compare the effects of oral and intravenous midazolam for upper gastrointestinal endoscopy (ugie) on children. methods: in this randomized clinical trial study conducted in amirkola children's hospital, 110 children were randomly assigned to oral or intravenous...

background: the use of intravenous sedatives is common in gastrointestinal endoscopy. this study is to evaluate the safety and ef_cacy of propofol and/or midazolam in induction of proper sedation in esophagogastroduodenoscopy (egd) compared with a control group, which does not receive sedation for egd. â  methods: four groups (a, b, c and d) of 30 patients each for whom egd had been indicated w...

Midazolam, a commonly used sedative and amnestic medication, has recently been shown to be largely metabolized in the liver by a cytochrome P450, termed CYP3A4. There is at least a tenfold intersubject variability in the liver content and catalytic activity of CYP3A4, which may in part account for the known interpatient differences in the kinetics of midazolam. To test this hypothesis, we deter...