The present study aimed to determine whether the expression of microRNA (miR)-10b was correlated with the molecular subtypes of early invasive ductal carcinoma of the breast. In situ hybridization was used to detect the expression of miR-10b in 193 patients diagnosed with early invasive ductal carcinoma. Immunohistochemistry was performed to evaluate the expression of estrogen receptor (ER)-α, ...

BACKGROUND There has been growing interest in the overdiagnosis of breast cancer as a result of mammography screening. We report incidence rates in British Columbia before and after the initiation of population screening and provide estimates of overdiagnosis. METHODS We obtained the numbers of breast cancer diagnoses from the BC Cancer Registry and screening histories from the Screening Mamm...

breast cancers (1). Moreover, it differs from invasive ductal carcinoma, the most common histologic subtype of breast cancer, not only with respect to histologic and mammographic characteristics, but also in the pattern of metastatic spread (2). While the spread to the lymph nodes, lung and liver is common in both ductal and lobular carcinomas, invasive lobular carcinoma has been found to metas...

When a total of 2488 Turkish patients were taken into consideration, carcinomas with apocrine differentiation accounted for 0.7% of invasive breast carcinomas. The aim of this study was to evaluate clinicopathologic features of this rare type breast carcinoma in Turkish population. To our knowledge, our study has a unique specialty as having broadest group of Turkish patients with apocrine carc...

PURPOSE Mucins are members of the glycoprotein family expressed in benign and malignant epithelial cells. The aim of this study is to evaluate the relationships between the expression of mucins in breast ductal carcinoma and clinicopathologic parameters. METHODS We constructed tumor microarrays based on 240 cases of invasive ductal carcinoma and 40 cases of ductal carcinoma in situ (DCIS) usi...

Objective : To determine the relations between human papilloma viruses type 16 and type 18 infection and the expression of p53 protein in invasive ductal carcinoma. Methods : We detected the expression of HPV 16/18 DNA and p53 protein in invasive ductal carcinoma in 45 cases, breast fibroadenoma in 20 cases and normal breast tissues in 20 cases. HPV detection was performed on paraffin sections ...

background: invasive ductal carcinoma is the most common type of breast cancer in iran. impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. it is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   objective: to analyze the status of tumor as...

INTRODUCTION The utility of FDG PET/CT for the detection and evaluation of invasive ductal carcinoma has been widely reported, but a few studies have assessed the utility of FDG PET/CT to detect malignancy in a variety of pancreatic lesions other than invasive ductal carcinoma. PURPOSE To compare the diagnostic performance of visual estimation with the semi-quantitative scores of FDG PET/CT f...

Spontaneous apoptosis by in situ detection of DNA fragmentation (DNAf) was investigated in breast invasive ductal carcinoma (IDC) frozen samples removed from 61 untreated patients. The incidence of DNAf was low in carcinoma cells and was mainly detected in the stroma. In the stroma at a distance from carcinoma cells, DNAf was inversely related to estradiol plasma level variations (p=0.01), indi...

The aim of this study was to investigate the value of quantitative 3-Tesla (3T) magnetic resonance (MR) assessment in the diagnosis of breast lesions. A total of 44 patients with breast lesions were selected. All the patients underwent MR plain scanning and T1 dynamic contrast-enhanced imaging. The vascular function parameters of the lesions, namely volume transfer constant (Ktrans), rate const...