Various meningococcal conjugate vaccines exist against serogroups A, C, W and Y. A new protein-based vaccine targeting serogroup B (MenB) is also now available. The potential of such vaccines to drive serogroup replacement is considered a possible public health concern when implementing nationwide routine immunization programmes. The aim of this work was to investigate if and how serogroup repl...

Objectives4CMenB is a broadly protective vaccine against invasive meningococcal capsular group B disease (MenB IMD). Licensed worldwide based on immunogenicity and safety data, effectiveness impact data are now available. We comprehensively reviewed all available real-world evidence gathered from use of 4CMenB since licensure.ResultsData 7 countries provide across different healthcare settings ...

IntroductionOutbreaks of invasive meningococcal disease (IMD) among men who have sex with (MSM) caused by a hypervirulent, non-encapsulated Neisseria meningitidis (Nm) clone belonging to genogroup C been described. We aimed determine the oral and anal carriage rates genogroups Nm MSM living HIV.MethodsSexually active HIV were included. A questionnaire, an wash sample swab collected at baseline ...

Epidemics of invasive meningococcal disease (IMD) caused by meningococcal serogroup A have been eliminated from the sub-Saharan African so-called "meningitis belt" by the meningococcal A conjugate vaccine (MACV), and yet, other serogroups continue to cause epidemics. Neisseria meningitidis serogroup W remains a major cause of disease in the region, with most isolates belonging to clonal complex...

AIM To review the epidemiology of invasive meningococcal disease in NSW for the period 1991-2011, in particular since the introduction of the meningococcal C vaccination program in 2003. METHODS We undertook a descriptive analysis of NSW notifications of invasive meningococcal disease for the period 2003-2011, and explored long-term changes in the epidemiology of invasive meningococcal diseas...

INTRODUCTION AND OBJECTIVES AND AIMS Invasive meningococcal disease (IMD) remains a serious public health problem. Although culture is the gold standard, previous antibiotic therapy reduces its sensibility. The aim of this study is the epidemiological analysis of IMD in our area, to assess the usefulness of polymerase chain reaction (PCR) to increase its diagnostic accuracy,and to show the asso...

I nvasive meningococcal disease (IMD) is an epidemic infectious disease highly influenced by climatic factors. Climate plays an important role in both the spatial distribution of the disease and in the seasonality of IMD as seen all over the world (1). It is mentioned as one of the infectious diseases likely to be affected by climate change in the Fourth Assessment report of the Intergovernment...

BACKGROUND Mortality from invasive meningococcal disease (IMD) has remained stable over the last thirty years and it is unclear whether pre-hospital antibiotherapy actually produces a decrease in this mortality. Our aim was to examine whether pre-hospital oral antibiotherapy reduces mortality from IMD, adjusting for indication bias. METHODS A retrospective analysis was made of clinical report...

PURPOSE The aim of this study was to identify environmental or genetic risk factors that are associated with invasive meningococcal disease (IMD) in children in Greece. METHODS A case-control study was performed in 133 children (44 cases and 89 controls) aged between 0-14 years, who were hospitalized in a children's hospital in Athens. Demographics and possible risk factors were collected by ...