The hypothesis is summarised schematically in Fig. 1. It is proposed that mechanical deformation of the skin by needles and application of heat or electrical current leads to release of large amounts of ATP from keratinocytes, fibroblasts and other cells in skin; the ATP then occupies specific receptor subtypes expressed on sensory nerve endings in the skin and tongue; the sensory nerves send i...

Autophagy is a lysosomal-driven catabolic process that contributes to preserve cell and tissue homeostases through the regular elimination of damaged, aged and redundant self-constituents. In normal cells, autophagy protects from DNA mutation and carcinogenesis by preventive elimination of pro-oxidative mitochondria and protein aggregates. Mutations in oncogenes and oncosuppressor genes dysregu...

To clarify the existence of HAM/TSP presenting amyotrophic lateral sclerosis (ALS)-like manifestations, we assayed HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) in 15 patients with anti-HTLV-I antibody in serum and ALS-like manifestations (upper motor neuron involvement in at least one region and lower motor neuron involvement in at least two limbs) by quantitative PCR, and ...

S-ry : Puhnonary functions in 169 youns maJesof Haryana~ sttad'ed with the help of a ~ter seal SpiromtCaand Wright's peak ftow met~. Different parametus anaJy5ed were FVC, FEVI~~ P.F.R•• MVV. and upiratory ftow rates behroun 25-SO~.. 25-75% ud SO-7S·. of FVC. Our mean "..lues are wdl comparable ",ith those of Indian worken but less thin thole reported by Western .on.... Pulmonary fuDClions t:()...

An efficient and numerically stable dual algorithm for positive definite quadratic programming is described which takes advantage of the fact lhat the unconstrained minimum of the objective function can be used as a starling point. Its implementation utilizes the Cholesky and QR factorizations and procedures for updating them. The performance of the dual algorithm is compared against that of pr...

Working memory is often defined in cognitive psychology as a system devoted to the simultaneous processing and maintenance of information. In line with the time-based resource-sharing model of working memory (TBRS; Barrouillet and Camos, 2015; Barrouillet et al., 2004), there is accumulating evidence that, when memory items have to be maintained while performing a concurrent activity, memory pe...

The “less is more” hypothesis suggests that one reason adults and children differ in their language acquisition abilities is that they also differ in other cognitive capacities: for instance, the relatively poor memory and/or processing abilities of children may make them more likely to over-regularize inconsistent input (Singleton & Newport, 2004; Hudson Kam & Newport, 2005). We investigate th...

Notrl' Dame Security/l'olict1 (NIJSI'I wolconwd the public Ttwsday morning to an open house for their nnw !wadquarters. llarnmns Mowbray llall, Thn headquarters, whirh also houses the new post oiTicn, is ilH~atnd across from t:tarllwr llall at tlw cornnr of lloly Cross and St. Joseph Drives. Though the open house was Tuesday. the new NDSP headquarters has been fully operational since Jan. 4. Th...