The first iodinated cyclopentadienone was isolated and its structure was confirmed by single crystal X-ray analysis. Based on this intermediate, the first direct C-C bond formation on cyclopentadienone ring was achieved. The photo induced intramolecular charge transfer of alkynylated cyclopentadienones was evaluated by solvent polarity effect on their electronic absorption spectra.

Although intensively studied, the high-resolution crystal structure of the peptide DFNKF, the core-segment of human calcitonin, has never been described. Here we report how the use of iodination as a strategy to promote crystallisation and facilitate phase determination, allowed us to solve, for the first time, the single-crystal X-ray structure of a DFNKF derivative. Computational studies sugg...

Direct iodination of benzothiazoles under strong oxidative/acidic conditions leads to a mixture iodinated heteroarenes with 1–2 major components, which are easily separable and structures depend on the I2 equivalents used. Among unexpected but dominant products were identified 4,7-diiodobenzothiazoles rare substitution pattern for SEAr reactions this scaffold. These employed in synthesis 4,7-bi...

background: to assess accessibility of iodinated salt and urinary iodine concentrations (uic) during pregnancy. this cross-sectional study was carried out between october and december, 2009 in urmia county, west azerbaijan (wa), iran. methods: data on demographic characteristics and iodinated salt accessibility were gathered through a questionnaire at 1st trimester. household salt samples and u...

The human epidermoid carcinoma cell line A431 has an usually high number of specific saturable receptor sites for the mitogenic polypeptide hormone epidermal growth factor (EGF). When A431 cells were treated with unlabeled EGF in the culture medium, approximately 50% of the EGF specific binding activity was lost within a few hours (receptor down regulation). A comparison of the surface proteins...

Studies with lactoperoxidase showed that a highly reactive intermediate is produced (on the enzyme) from I- and H2O2 which then diffuses from the enzyme and very rapidly and indiscriminately iodinates any Tyr or peptides containing Tyr which are in the same solution. The evidence supporting these conclusions follows. 1) The rate followed the Michaelis-Menten pattern with I- and H2O2 while the c...

Ribosomal proteins L7 and L12 are involved in the initiation, elongation and termination of polypeptide synthesis [l-6]. These acidic proteins do not function independently, but act in concert with the ribosome to perform the above steps. These observations suggest that L7 and L12 are necessary to maintain the conformational integrity of the ribosome, and that loss of ribosomal activity followi...