The study was aimed to prepare gastro retentive floating microsphere of Ranitidine Hydrochloride by Ionotropic Gelation technique and solvent evaporation using the different carriers’ ratios (Carbopol 934, Chitosan, sodium alginate). Both natural synthetic polymers have been used microspheres evaluated relevant parameters. There no drug carrier interactions assessed from FTIR. Depending upon ra...

В работе методом ионотропного гелеобразования синтезированы стабильные наночастицы хитозана. Изучены свойства образца хитозана - определены его степень дезацетилирования (83,7%), а также относительная и характеристическая вязкости растворов. Определены размеры наночастиц дзета-потенциал динамического рассеяния света. Проведено исследование влияния соотношений реагентов триполифосфата натрия на ...

In order to achieve prolong corneal contact time of norfloxacin (NFX) for treatment of extra ocular diseases, a pH triggered nanoparticulate in-situ gelling system was designed to explore dual advantage of nanoparticles and in-situ gelling system, for its ocular delivery. NFX loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-li...

Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise t...

Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties. However, the poor aqueous solubility and low bioavailability of curcumin have limited its potential when administrated orally. In this study, curcumin was encapsulated in a series of novel ...

Chlorella pyrenoidosa is a unicellular green algae and has been a popular foodstuff worldwide. However, no reports on the antitumor peptides from such a microalgae are available in the literature. In this study, using low-temperature high-pressure extraction, enzymatic hydrolysis, ion exchange, and gel filtration chromatography, we separated a polypeptide that exhibited inhibitory activity on h...

Aim: The objective of the present study is to design and evaluate mucoadhesive microspheres for oral controlled release. Materials and Method: Rosiglitazone maleate microspheres with a coat consisting of alginate and a mucoadhesive polymer sodium carboxymethylcellulose, carbopol 934P and hydroxypropylmethylcellulose were prepared by an orifice-ionic gelation process. The microspheres were evalu...

Background: Prednisolone (PRD) is orally prescribed for inflammatory bowel syndrome (IBS) as the upper GIT main site of absorption; therefore, long-term PRD dosing decreases therapeutic effectiveness through systemic side effects. Objective: This work focused on formulating sustained-release alginate beads a multiparticulate system colon targeting using prednisolone to be filled in an HPMC caps...

Chitosan is a linear polysaccharide with prominent physicochemical and biological properties such as biocompatibility, biodegradability, nontoxicity, nonimmunogenicity, bioadhesion, antibacterial, antifungal, hemostatic activity. Due to these properties, it has found many applications in cosmetic, textile, food industries; agriculture; biotechnology; pharmaceutical industry medicine, especially...