Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where Hh signaling occurs either directly within the cancer cells or within the nonmalignant cells of the tumor microenvironment. Chondrosarcoma is a malignant tumor of cartilage in which there is ligand-dependent activation of Hh signaling. IPI-926 is a potent, orally del...

BACKGROUND In the rituximab era, the conventional International Prognostic index (IPI) lost at least in part its predictive power, while the National Comprehensive Cancer Network-IPI (NCCN-IPI) seems to be a new and valid prognosticator. However, it has not yet been evaluated in patients with localized disease and it has not been compared with the modified IPI (mIPI) of the pre-rituximab era. I...

In this paper we study the information theoretic capacity of Pulse Position Modulation (PPM) Ultra Wideband (UWB) communications for single user channels. The capacity is studied with a link impulse response with delay spread and Inter Pulse Interference (IPI). The objective is to consider the effect of IPI on capacity and quantify the capacity with IPI. An expression for the signal-tonoise rat...

Methods Women with ESBC were treated 7-10 days preceding mastectomy with either cryo (n=6), single-dose ipi at 10mg/kg (n=6), or cryo+ipi (n=6) [6]. From serial blood (baseline & 1-month post-mastectomy) and tumor (biopsy & mastectomy), fold-changes following cryo+ipi versus monotherapy were compared (Wilcoxon ranksum) across the following measures: Ki67+ or ICOShi T-cells [2] and intratumoral ...

The purpose of this study was to determine the efficacy of providing (i) tailored injury prevention information (T-IPI) to parents and (ii) concurrent T-IPI to parents and providers to promote parent adoption of safety practices. During well-child visits, parents of children ages 4 and younger completed a computer assessment and were randomized to receive generic injury prevention information, ...

Abstract Objectives Our objectives were to analyze how pregnancy outcomes varied by cesarean birth as compared vaginal across varying interpregnancy intervals (IPI) and determine if IPI modified mode of birth. Methods This secondary analysis used data from a prospective registry home hospital births in Chimaltenango, Guatemala January 2017 through April 2020, the Global Network for Women’s Chil...

We have developed a calculus, called Ipi, for describing the aberrance in biological models. Our approach extends the traditional pi calculus to handle aberrant process in the signal transduction. In this paper we propose a typing system that replaces the tag system of Ipi calculus. It is shown that the typing system is equal to the tag system in terms of the expressive power.

Phosphoinositide 3-kinases g and d (PI3Kg and PI3Kd) are expressed in rheumatoid arthritis (RA) synovium and regulate innate and adaptive immune responses. We determined the effect of a potent PI3Kd,g inhibitor, IPI-145, in two preclinical models of RA. IPI-145 was administered orally in rat adjuvantinduced arthritis (AA) and intraperitoneally in mouse collageninduced arthritis (CIA). Efficacy ...

BACKGROUND Economic evaluations often measure an intervention effect with mean overall survival (OS). Emerging types of cancer treatments offer the possibility of being "cured" in that patients can become long-term survivors whose risk of death is the same as that of a disease-free person. Describing cured and noncured patients with one shared mean value may provide a biased assessment of a the...