We construct efficient designs for the Michaelis-Menten enzyme kinetic model capable of checking model assumption. An extended model, called EMAX model is also considered for this purpose. This model is widely used in pharmacokinetics and reduces to the MichaelisMenten model for a specific choice of the parameter setting. Our strategy is to find efficient designs for estimating the parameters i...

The first liver transplantation (LT) was performed by Thomas E Starzl five decades ago, and yet it remains the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF) and certain early-stage liver tumors. Post-liver transplantation survival has also dramatically improved over the last few decades despite increasing donor and reci...

<p><strong>Background.</strong> Innovation platforms (IP) are a set-up where group of stakeholders that somewhat interdependent identified and invited to get together interact in forum for social learning. However, Sub-Saharan African researchers have recently paid very little attention its participation. <strong>Objective.</strong> To investigate the determinants ...

CAD/CAM technology in dentistry offers high-end ceramic restorations, known for its quality, preciseness, swiftness and repeatability. However, some features are still human-dependent. A young female patient required smile enhancement, since suffering from colour change on three devitalized frontal teeth. After fiber post placement, teeth were prepared for metal-free restoration. Consequently, ...

Methods This retrospective study included subjects with PAH who a cardiac magnetic resonance (CMR) study within 14 days of cardiac catheterization between January 2009-August 2013. The effective elastance (Ea, index of arterial load) and right ventricular maximal end-systolic elastance (Emax, index of contractility) were determined by a combination of CMR and hemodynamic data. Ea is defined as ...

Abstract Background In patients with severe aortic stenosis (AS), an anatomic and functional staging classification has been proposed to assess extent of cardiac chambers damage improve the decision valve replacement based only in symptoms or ejection fraction (EF) <50%. This relies on concept that left ventricular (LV) afterload secondary AS induce LV dysfunction progression right damag...

STATEMENT OF PROBLEM Information is lacking about the fatigue resistance of computer-aided design and computer-aided manufacturing (CAD-CAM) tooth-colored implant custom abutment materials. PURPOSE The purpose of this in vitro study was to investigate the reliability of different types of CAD-CAM tooth-colored implant custom abutments. MATERIAL AND METHODS Zirconia (Lava Plus), lithium disi...

OBJECTIVE The purpose of this study was to determine the effect of two extraoral computer-aided design (CAD) and computer-aided manufacturing (CAM) systems, in comparison with conventional techniques, on the marginal fit of monolithic CAD/CAM lithium disilicate ceramic crowns. STUDY DESIGN This is an in vitro interventional study. PLACE AND DURATION OF STUDY The study was carried out at the...

Aim. The purpose of this study is to investigate the effects hydrofluoric acid and one-component ceramic primer silane (Monobond Etch Prime (MEP)) applications on lithium disilicate glass ceramics zirconium-infiltrated silicate ceramics, as well effect ultrasonic phosphoric surface washing methods bond strength. Materials Method. A total 240 samples were prepared using two different CAD-CAM mat...

This study for the first time achieved an emission spectrometric analysis of the chemiluminescence of flavonoids in the presence of hydrogen peroxide, acetaldehyde and horseradish peroxidase, and revealed that the maximum emission wavelengths (Emax) strictly differ among catechins (E-max 630 nm), theaflavins (Emax 690 nm) and anthocyanins (Emax 675 nm) according to their chemical structures. Th...