The concentration of ferritin in serum gives a quantitative measure of the amount of storage iron in normal subjects and those with iron deficiency or overload. The mean level in normal men is 69 ng/ml, compared with 35 ng/ml in normal women. A concentration below 10 ng/ml is associated with a low transferrin saturation and iron-deficient erythropoiesis.

CONRAD,MARCEL E., ARTHUR L. FOY, HAROLD L. WILLIAMS, AND WILLIAM H. KNOSPE. Effect of starvation and protein depletion on ferrokinetics and iron absorption. Am. ‘J. Physiol. 213(3) : 557565. 1967.-Starvation and protein-deficient diets caused marked ferrokinetic abnormalities and decreased absorption of iron. Observations at intervals after the onset of fast and in rats fed various amounts of p...

Isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µM) to assess the changes in reactive oxygen species (ROS) and lipid peroxidation leading to apoptotic hepatocyte cell death. The viability of hepatocytes was declined depending on the iron concentration. One hour incubation of the cells with 100 µM iron resulted in decreased...

Isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µM) to assess the changes in reactive oxygen species (ROS) and lipid peroxidation leading to apoptotic hepatocyte cell death. The viability of hepatocytes was declined depending on the iron concentration. One hour incubation of the cells with 100 µM iron resulted in decreased...

Over the past 30 years, tubewells have become a ubiquitous source of potable groundwater in South Asia. Considered safer than surface water, groundwater naturally contains minerals that may impact human health; however, few data exist on tubewell water mineral content or its association with human nutritional or health conditions. We surveyed iron concentration in tubewell water across a 435 km...

PURPOSE Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death, and iron overload is a significant risk factor in the development of HCC. In this study, we investigated the potential application of depriving iron by a novel iron chelator, thiosemicarbazone-24 (TSC24), in HCC treatment. EXPERIMENTAL DESIGN Two HCC cell lines and HFE knockout (HFE(-/-)) mice were ...

An in vitro digestion/Caco-2 cell model was used to assess iron bioavailability of twenty elite latematuring tropical maize varieties grown in three diverse agroecologies in West and Central Africa (WCA). Kernel-iron concentration of the varieties, averaged across locations, varied from 19.2 to 24.4 mg kg−1, while mean kernel-zinc concentration ranged between 19.4 and 24.6 mg kg−1. Significant ...

Determination of serum ferritin is an important means of assessing body iron stores. Trace amounts of ferritin normally present in serum are detectable by sensitive radioimmunoassay techniques or an enzyme immunoassay procedure. Ferritin normally accounts for no more than a very small fraction of the total iron in serum, but generally maintains a stable concentration that is proportional to the...

Rabbit transferrin in vitro is shown to load ferrous iron at random on its specific binding sites. The release of iron to reticulocytes is shown to be an all-or-none phenomenon. The two monoferric transferrins have similar in vivo plasma iron clearance rates and tissue distribution. Diferric transferrin, while giving a similar tissue distribution of radioiron, has a plasma iron clearance rate a...

OBJECTIVE To evaluate the efficacy of IV iron supplementation of anemic, critically ill trauma patients. DESIGN Multicenter, randomized, single-blind, placebo-controlled trial. SETTING Four trauma ICUs. PATIENTS Anemic (hemoglobin < 12 g/dL) trauma patients enrolled within 72 hours of ICU admission and with an expected ICU length of stay of more than or equal to 5 days. INTERVENTIONS Ra...