introduction: renal ischemia reperfusion is considered to be one of the causes of acute renal failure (aki). in addition, renal ischemia is an important incident usually occurs due to renal transplantion, repair of suprarenal aneurysm, hemorrhagic shock. a recent study reported that reactive oxygen species (ros) are important mediators of aki. it seems essential to use antioxidant to decrease t...

background: ischemia reperfusion (ir) is the main pathology of torsion of testis and it is a common urologic emergency. there is some evidence that shows oxytocin (ot) plays role in ischemia reperfusion. objective: to evaluate this hypothesis that ot can decrease germ cell apoptotic index in testis under acute ischemia reperfusion in a rat model. materials and methods: 20 adult rats were random...

introduction: preliminary studies have con.rmed reduction in cell death following treatment with antioxidants. according to this .nding we study the relationship between consumption of coq10 and expression of bax and bcl2 in hippocampus following ischemia/reperfusion as proteins involved in cell programmed death or apoptosis. methods: we studied the protective role of coq10 against ischemia-rep...

Objective(s) The aim of this study was to investigate the overall effect of cardiac vasoactive factors during coronary occlusion and reperfusion on peripheral vascular tone, using a sequential isolated rabbit heart-ear perfusion model. Materials and Methods Isolated ears were perfused with the effluent of isolated hearts subjected to ischemia (30 min) and reperfusion (180 min, n=6). The comp...

Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They are implicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheral organs such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects against ischemia–reperfusion injury in many organs. The goal ...

Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor b...

Background & Target: Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on bcl2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated.Methods: In this experimental study, 20 male wistar rats with average weight of...

We investigated the metabolism of mouse isolated heart under influence tricarbonyldichlorothenium (II)- dimer (CORM-2 and 2,3-4,5-bis-O-isopropylidene-βD-fructopyranose sulfamate (topiramate) as potential blockers aquaporine channel (AQP3) cardiac myocytes. The results were compared with those obtained from group receiving anti-AQP3 monoclonal antibodies. A decrease in coronary flow was found d...

Objective(s): The aim of the present study is to investigate probable acute effects of vitamin D on ischemia-reperfusion injury in the rat ovary.Materials and Methods: A group of 30 Wistar albino rats was divided into five groups of 6 each. Group 1:  underwent laparotomy only and the ovaries were removed. Group 2:  3-hr ischemia followed by excision of the ovaries. Group 3:  3-hr ischemia and 3...

Background & Target: Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on bcl2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated.Methods: In this experimental study, 20 male wistar rats with average weight of...