Background: Liver ischemia / reperfusion Injury (IRI) is one of the major causes of liver failure during various types of liver surgery, trauma and infections. The present study investigates the effect of dexsamethasone on the liver injury and inducible nitric oxide synthase gene expression during hepatic warm ischemia/reperfusion in rats. Materials and Methods: 24 male Wistar rats (200-250 g)...

Chronic stress in humans has been correlated with increased risk for ischemic heart disease. Thus experiments were conducted to determine if repeated intermittent restraint stress increased infarct size in a rat model of myocardial ischemia-reperfusion injury. Male Sprague-Dawley rats were subjected to no stress (control) or to daily restraint stress for 1-1.5 h for 8-14 days (stress protocol A...

results the basic mechanism of hepatic ischemia – reperfusion injury is one of blood deprivation during ischemia, followed by the return of flow during reperfusion. it involves a complex series of events, such as mitochondrial deenergization, adenosine-5'-triphosphate depletion, alterations of electrolyte homeostasis, as well as kupffer cell activation, oxidative stress changes and upregulation...

conclusions our study demonstrates that preconditioning of kidney with chronic ptu administration protects renal tissue against iri and this phenomenon was mediated through no system. the results suggest a potential indication for using ptu to protect the kidney before transplantations and to reduce the risk of tissue rejection afterwards. background renal ischemia/reperfusion injury (iri) is a...

Myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. The present study was investigated potential resistance to ischemia-reperfusion (I/R) injuries following administration of methanolic (MeOH) extract of Scrophularia frigida (S. frigida) in isolated rat heart. Male Wistar rat hearts (n= 8-10) were isolated and allowed to equilibrat...

objectives:vagal pathways in gastrointestinal tract are the most important pathways that regulate ischemia/reperfusion (i/r).  gastrointestinal tract is one of the important sources of melatonin production. the aim of this study was to investigate probable protective effect of the interaction between vagus nerve and melatonin after i/r. materials and methods:this study was performed in male rat...

conclusions treatment with epo and mel had a beneficial effect on renal ir injury. the results may also indicate that mel protects against morphological damage better than epo in renal ir injury. results ischemia-reperfusion significantly decreased the observed hb and hct values. the histopathological findings in the ir group confirmed that there was an increase in the hyaline cast and thickeni...

aim: oxidative stress plays a crucial role in the pathophysiology of ischemic stroke. since water-solublefullerene derivatives act as the potent scavenger of oxygen free radicals in biological systems, we aimedto investigate the possible protective effects of fullerol nanoparticles on brain infarction and edema intransient model of focal cerebral ischemia in rat.materials & methods: experiment ...

introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...