introduction: several studies have indicated that late treatment of aminoguanidine (ag) reduces cerebral ischemic injuries in animal models. however, the effects of early treatment of ag on cerebral ischemic damage are not well understood. this study was designed to evaluate effect of early treatment of ag on cortex and striatum injuries as well as neurological dysfunctions in transient model o...

Ischemia-reperfusion injuries (IRI) occur in different clinical conditions such as stroke, trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen depletion in tissues. The lack of oxygen as the last acceptor of electron in the respiratory chain causes a decrease in ATP production and eventually leads to disruption of membrane transport, acidosis, cellular edema and ...

Ischemia-reperfusion not only damages the affected organ but also leads to remote organ injuries. Hepatic inflow interruption usually occurs during hepatic surgery. To investigate the influence of liver ischemia-reperfusion on lung injury and to determine the contribution of tidal volume settings on liver ischemia-reperfusion-induced lung injury, we studied anesthetized and mechanically ventila...

In a rat model of myocardial ischemic infarction, sodium orthovanadate rescued cells from ischemia/reperfusion injuries. Rats underwent 30 min of myocardial ischemia by occluding the left coronary artery followed by 24 h of reperfusion. Post-treatment with orthovanadate reduced infarct size in a dose-dependent manner. Orthovanadate treatment also ameliorated contractile dysfunction of the left ...

Purpose: To evaluate the protective action of alpha-tocopherol in ischemia/reperfusion injuries of pelvic member of rats. Methods: Thirty adult male rats of the Wistar strain were randomized into three experimental groups of 10: Group I – control group with no ischemia or reperfusion. Groups II and III – four hours of ischemia and of hours of reperfusion by means of clamping of the infrarenal a...

hepatic ischemia-reperfusion (i/r) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. mechanisms involved in i/r damage are very intricate and cover several aspects. several factors are involved in i/r-induced damages; briefly, decrease in sinusoidal perfusion and atp generatio...

background: angiotensin ii (ang ii) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. this study evaluated the role of central ang ii by using candesartan, as an at1 receptor blocker, in the brain edema formation and blood-brain barrier (bbb) disruption caused by ischemia/reperfusion (i/r) injuries in rat. methods...

introduction: in the current study, protective effect of natural honey applied during ischemia/reperfusion (i/r) was studied on infarct size in ischemic heartheart. methods: ischemic hearthearts (n=8 per group) were mounted on a langendorff apparatus at constant pressure then subjected to 30 min regional ischemia followed by 120 min reperfusion. in control group, the hearts were perfused by a m...

objective: it is generally agreed that most of the phenomena observed during brain ischemia and reperfusion can be explained by the damage to membrane structure. oxidative stress is resulted in an imbalance between high consumption of oxygen and low levels of endogenous antioxidants. it is known that gallic acid (ga) is a strong antioxidant. the present study was carried out to evaluate the eff...

BACKGROUND Organ injury occurs not only during periods of ischemia but also during reperfusion. It is known that ischemia reperfusion (IR) causes both remote organ and local injuries. OBJECTIVE This study evaluated the effects of tramadol on the heart as a remote organ after acute hindlimb IR. METHODS Thirty healthy mature male Wistar rats were allocated randomly into three groups: Group I ...