introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...

Tourniquets are used in extremity surgery and provide a relatively bloodless field, thereby minimizing blood loss and helping identify the vital structures. However, they may cause an ischemia-reperfusion injury with potentially harmful local and systemic consequences. Many therapeutic effects such as diuretic, natriuretic, hypotensive, anti-rheumatic, anti-prostatic, and in-vitro anti-oxidant ...

BACKGROUND We aimed to investigate the effects of curcumin on ischemia/ reperfusion (IR) injury of the liver and distant organs resulting from liver blood flow arrest. MATERIALS AND METHODS Totally 40 rats, divided into four groups, each included 10 rats were used. Group I as only laparatomy, Group II laparatomy and curcumin application, Group III hepatic IR; and Group IV as hepatic IR and cu...

conclusions the analysis of the pro-apoptotic gene to anti-apoptotic gene expression ratio (bad /bcl-xl) confirmed that expression of the pro-apoptotic gene significantly decreased (p value ˂ 0.001) under the ischemia/reperfusion condition. in contrast, the expression of the anti-apoptotic gene increased after administration of fk-506 (p value ˂ 0.001). results the quantitative results of real-...

A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with...

objective(s): the alteration of glucose transporters is closely related with the pathogenesis of brain edema. we compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(glut-1)-immunoreactive microvessels in their ischemic hippocampal ca1 region. materials and methods: transient cere...

Renal ischemia-reperfusion (IR) causes remote liver damage. Oxytocin has anti-inflammatory and antioxidant effects. The main purpose of this study was to evaluate the protective function of oxytocin (OT) in remote liver damage triggered by renal IR in rats. Twenty four rats were randomly divided into four different groups, each containing 8 rats. The groups were as follows: (1) Sham operated gr...

ischemia has an important role in spread of pathologic injuries in the neuropathies. it is widely accepted that most damages such as reperfusion injuries, are related to the activity of free radicals. apoptotic signaling was exacerbated by free radicals. the aim of this study was to evaluate the neuroprotective effect of human chorionic gonadotropin (hcg) and vitamin e (trolox) in the hippocamp...

Objective(s): To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (IR) injury. Materials and Methods: Eighteen female Wistar albino rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the erdosteine for seven da...