OBJECTIVE To study prognostic characteristics of cardiac troponin I (cTnI) elevation in acute ischemic stroke. METHODS We retrospectively studied patients (n = 248) with acute ischemic stroke, acute ST-segment elevation myocardial infarction, and acute non-ST-elevation myocardial infarction who were treated between January 2013 and October 2015. Baseline demographic data and changes in cTnI l...

Previously, one of the authors developed a reliable experimental model in dogs for producing cerebral infarction. The EEG increased detection of experimental cerebral infarction, and was useful in predicting ischemic regions or infarction.

Background: Stroke is known to be the third most prominent cause of death in the developing countries and the most common debilitating neurologic disease. This study aimed to investigate the association of platelet count (PC) and mean platelet volume (MPV) index with various stroke types. Methods: This cross-sectional study was carried out on patients over the age of 18 years who presented wit...

In Japan the incidence of myocardial infarction or Q1-1 of Minnesota Code is 0.24%-0.54% in epidemiological survey, and the incidence of total cases with Q1-1•`Q1-3 is about 1.0%. The incidence of ischemic heart disease in epidemiological survey is 2.1 %, and the death from arteriosclerotic heart disease including coronary heart disease (B26a) in vital statistics is 3.7%. The incidence of repor...

BACKGROUND AND PURPOSE Superoxide has been implicated in the pathogenesis of ischemic stroke and atherosclerosis. NADPH oxidase, a major source of superoxide generation in neutrophils and the vascular system, plays a critical role in ischemic injury and atherogenesis. Recently, an association between the C242T polymorphism of p22 PHOX, an essential component of NADPH oxidase, and coronary arter...

BACKGROUND Pre-infarction angina reduces myocardial infarct size by preventing the myocardium from being subjected to ischemia reperfusion (I/R) injury. Ischemic preconditioning is the proposed mechanism for this effect. Sphingosine 1 phosphate (S1P) activates ischemic preconditioning pathways and may play a role in the presence of cardioprotective effects of pre-infarction angina. Therefore, w...

BACKGROUND Lacunar infarctions account for up to 25% of all ischemic strokes and, thus, constitute a numerically important subgroup. It is important that the two pathogeneses of lacunar infarction, that is, small-vessel occlusion and branch atheromatous disease, be differentiated because prognoses and treatment strategies differ. The authors evaluated the presence of branch atheromatous plaque ...

Hemorrhagic infarction subsequent to ischemic brain damage, even if small, slight, or marbled, can be detected by CT. The mechanisms that give rise to this transformation in humans are not well elucidated. Previous reports indicate that hemorrhagic infarction is most common in embolic stroke and large infarcts, and can worsen the clinical state of ischemic patients. We examined 36 patients with...