نتایج جستجو برای: isoforms
تعداد نتایج: 31177 فیلتر نتایج به سال:
In subprimates, a single form of tyrosine hydroxylase (TH) is expressed, whereas two TH protein isoforms have been identified in monkeys and four isoforms have been demonstrated in humans. In order to establish the evolutionary pattern/emergence of these multiple TH isoforms, adrenal medullae from different mammalian species were analyzed by blot immunolabeling using pan-specific TH antibodies ...
Gastrointestinal cells express a diverse group of protein kinase C (PKC) isoforms that play critical roles in a number of cell functions, including intracellular signaling and barrier integrity. PKC isoforms expressed by gastrointestinal epithelial cells consist of three major PKC subfamilies: conventional isoforms (alpha, beta1, beta2, and gamma), novel isoforms (delta, epsilon, theta, eta, an...
Abstract In the past several years, nanopore sequencing technology from Oxford Nanopore Technologies (ONT) and single-molecule real-time (SMRT) Pacific BioSciences (PacBio) have become available to researchers are currently being tested for cancer research. These methods offer many advantages over most widely used high-throughput short-read approaches allow comprehensive analysis of transcripto...
Gastrointestinal cells express a diverse group of protein kinase C (PKC) isoforms that play critical roles in a number of cell functions, including intracellular signaling and barrier integrity. PKC isoforms expressed by gastrointestinal epithelial cells consist of three major PKC subfamilies: conventional isoforms ( , 1, 2, and ), novel isoforms ( , , , , and ), and atypical isoforms ( , , and...
The Omega class of glutathione transferases (GSTs) forms a distinct within the cytosolic GST superfamily because most them possess catalytic cysteine residue. human 1 isoform was first characterized twenty years ago, but it took work to clarify roles isoforms. Concerning kingdom fungi, little is known about cellular functions (GSTOs), although they are widely represented in some these organisms...
Transcription and alternative splicing (AS) are now appreciated in plants, but few studies have examined the effects of changing ploidy on transcription AS. In this study, we showed that artificially autododecaploid plants London plane (Platanus × acerifolia (Aiton) Willd) had flowers relative to their hexaploid progenitors. Transcriptome analysis based full-length Oxford Nanopore Technologies ...
In article number 2010225, Manuel Salmeron-Sanchez and co-workers develop hydrogels that incorporate specific laminin isoforms. Laminins are ECM molecules tissue specific, promote integrin binding, sequester growth factors. The versatility of the system to engineer in vitro 3D cultures controlled stiffness mesenchymal stem cell differentiation (using LM 521) or neural 411) is demonstrated.
The c-Jun NH(2)-terminal kinases (JNKs) have a role both in promoting apoptosis and tumorigenesis. The JNKs are encoded by three separate genes (JNK1, 2, and 3), which are spliced alternatively to create 10 JNK isoforms that are either M(r) 55,000 or 46,000 in size. However, the functional significance and distinct role for each splice variant remains unclear. We have noted previously that 86% ...
Due to alternative splicing events in eukaryotic species, the identification of mRNA isoforms (or splicing variants) is a difficult problem. Traditional experimental methods for this purpose are time consuming and cost ineffective. The emerging RNA-Seq technology provides a possible effective method to address this problem. Although the advantages of RNA-Seq over traditional methods in transcri...
Agonist stimulation of smooth muscle is known to activate RhoA/Rho kinase signaling, and Rho kinase phosphorylates the myosin targeting subunit (MYPT1) of myosin light chain (MLC) phosphatase at Thr696 and Thr853, which inhibits the activity of MLC phosphatase to produce a Ca2+ independent increase in MLC phosphorylation and force (Ca2+ sensitization). Alternative mRNA splicing produces four MY...
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