Isoetin derivatives are a rare class of flavonoids with rather erratic occurrence across the plant kingdom. The Cichorieae tribe Asteraceae family has proven to be rich source and centre chemical diversity this compounds. Here, we describe chromatographic isolation mainly NMR-based structure elucidation previously undescribed isoetin derivative from Leontodon hispidus L. (Asteraceae, Cichorieae...

Background and objectives: The genus Johrenia belongs to Umbelliferae family and contains five species that are endemic to Iran. Johrenia paucijuga grows widely in the north-west, west and center of Iran. So far, there has been no research about phytochemistry of J. paucijuga. In the present study, phytochemicals of the plants have been isolated and their structures h...

We describe the isolation and characterisation of novel non-benzoquinone ansamycin metabolites related to geldanamycin from a culture of Streptomyces sp. S6699. The compounds possess potent inhibitory activity in a cell-based assay measuring inhibition of oncostatin M signalling in a reporter cell line utilising a secreted placental alkaline phosphatase (sPAP) readout. In this paper we report t...

androstane skeleton with a keto-enol tautomerism at the cyclopentane ring. Wecarried out further isolation for PFTase inhibitors from the cultured broth of strain FO-3929 and found andrastin D (4, Fig. 1). In this paper, fermentation, isolation, structure elucidation, and biological properties of 4 are described. A stock culture of strain FO-3929 was inoculated into six 500-ml Erlenmeyer flasks...

Purification of the n-BuOH fraction of the aqueous alcoholic extract from the roots of Phytolacca americana resulted in the isolation of two triterpene saponins named esculentoside B (1), and esculentoside A (2). The structures of isolated compounds were characterized on the basis of extensive spectral data (1D and 2D NMR; and MS) and in comparison with their Nuclear Magnetic Resonance (NMR) an...