In addition to their anti-bacterial action, tetracyclines also have complex biological effects, including the modification of mitochondrial protein synthesis, metabolism and gene-expression. Long-term clinical studies have been performed using tetracyclines, without significant side effects. Previous studies demonstrated that doxycycline (DOX), a major tetracyclin antibiotic, exerted a protecti...

The effects of isoproterenol were examined in 10 conscious, chronically instrumented adult dogs with left ventricular (LV) failure after pressure overload hypertrophy induced by aortic banding at 8-10 weeks of age (LV free wall plus septum-to-body weight ratio, 8.6 +/- 0.5 g/kg) and also in eight control dogs (LV free wall plus septum-to-body weight ratio, 5.1 +/- 0.3 g/kg). Baseline values of ...

Indigofera cassioides Rottl. Ex. DC. is a large shrub, distributed throughout the hills of India. Because its reported robust antioxidant potential and phytoconstituents content, we were interested in investigating vitro thrombolytic vivo cardioprotective effect methanolic leaves extract cassioides. An model was used to evaluate clot lysis different concentrations along with streptokinase as po...

Purpose: Renin-angiotensin-aldosterone-system activation associated with heart failure is one of the main determinants health condition deterioration patients failure. The aim this study to compare effectiveness metallo-endopeptidase inhibitor Sacubitril alone and in combination azilsartan ameliorating syndromes rats.Materials Methods: twenty four rats were divided into 4 groups, each 6 rats. f...

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a major health problem associated substantial morbidity and mortality. However, the underlying pathophysiological mechanisms are poorly understood, effective treatment strategies scarce. Importantly, SGLT2i, which have been suggested to improve cellular Na Ca homeostasis in HFrEF, recently shown also clinical outcomes...

The enzymatic activity of the mitochondrial oligomycin-sensitive ATPase was investigated during isoproterenol-induced cell injury of myocardium, using rat heart homogenates and a potentiometric method. The enzymatic activity of the oligomycin-sensitive ATPase and the inhibitory action of oligomycin do not show significant alterations upon treatment with isoproterenol. These results are inconsis...

Myocardial ischemia causes both systolic and diastolic dysfunction. A variety of positive inotropic agents with different subcellular mechanisms may be used clinically in an attempt to reverse ischemic contractile failure. We tested the hypothesis that two inotropic agents, isoproterenol (a beta-adrenergic agonist) and ouabain (a sodium pump inhibitor), might have different effects on left vent...

Antioxidant role of Arogh in isoproterenol induced myocardial infarction in rats has been studied. The activity of heart tissue antioxidants like glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase were significantly decreased in isoproterenol administered group. The activity of ceruloplasmin and levels of glutathione, vitamins E and C were also fou...

Expression of a cohort of disease-associated genes, some of which are active in fetal myocardium, is considered a hallmark of transcriptional change in cardiac hypertrophy models. How this transcriptome remodeling is affected by the common genetic variation present in populations is unknown. We examined the role of genetics, as well as contributions of chromatin proteins, to regulate cardiac ge...

Heart failure is a disease predominantly caused by an energy metabolic disorder in cardiomyocytes. The present study investigated the inhibitory effects of fenofibrate (FF) on isoproterenol (ISO)‑induced hear failure in rats, and examined the underlying mechanisms. The rats were divided into CON, ISO (HF model), FF and FF+ISO (HF animals pretreated with FF) groups. The cardiac structure and fun...