PURPOSE A previously published study demonstrated a pharmacogenetic association between the minor alleles of 2 VEGFR2 single nucleotide polymorphisms (SNPs) and greater improvement in visual acuity (VA) to treatment with ranibizumab, an anti-vascular endothelial growth factor (VEGF) drug, in patients with neovascular age-related macular degeneration (AMD). We evaluated whether this association ...

This paper presents a methodology for using hydrodynamic modeling to estimate inundation areas and water depths during a hurricane event. The Environmental Fluid Dynamic Code (EFDC) is used in this research. EFDC is one of the most commonly applied models to Gulf of Mexico estuaries. The event with which the hydrodynamic model was tested was hurricane Ivan. This hurricane made landfall at the A...

A large number of medical experiments have confirmed that the features drugs a close correlation with their molecular structure. Drug properties can be obtained by studying structure corresponding drugs. The calculation topological index chemical graph enables scientists to better understanding physical chemistry and biological characteristics In this paper, we focus on Hyaluronic Acid-Curcumin...

INTRODUCTION I first heard the term ‘Asperger syndrome’ 20 years ago when I accompanied my sister-in-law Elizabeth and her son Ivan on a visit to a child psychiatrist. Ivan was 19 years old and had an odd pattern of behaviours since childhood. As none of the experts he had seen had been able to clearly diagnose his problem, we hoped that this new consultation would give a better insight into hi...

By the early 16th century, the Ottoman Empire had emerged as a major military power in Southeastern Europe and the Middle East. The Ottomans were feared and admired by contemporaneous Europeans from Niccol6 Machiavelli to Ivan Peresvetov. The latter regarded the empire of Sultan Mehmed II (r. 1444-46, 1451-81) as a model to be emulated by his own ruler, Ivan IV of Muscovy (r. 1547-84), and inde...

Ivan Cibrario Bertolotti IEIIT-CNR – Istituto di Elettronica e di Ingegneria dell’Informazione e delle Telecomunicazioni 11.

All animals have an effect on the environment, but some key species – called ecosystem engineers – can have a particularly large influence. Their impact can be positive, by creating and maintaining habitats and increasing biodiversity, but they can also be negative, by destroying habitats and reducing biodiversity. Interestingly, the magnitude of the effect that an ecosystem engineer has on the...

Ognjen Ilic,1,* Marinko Jablan,2 John D. Joannopoulos,1 Ivan Celanovic,3 Hrvoje Buljan,2 and Marin Soljačić1 1Department of Physics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA 2Department of Physics, University of Zagreb, Bijenička c. 32, 10000 Zagreb, Croatia 3Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology,...

Ivan Havel remembers when in the late 1970s the Czechoslovakian state police began watching his apartment. For months he had been hosting unofficial science seminars, and the police didn't like it. "It politicized me, says the soft-spoken computer scientist and brother of Czechoslovakian president Vaclav Havel. "The police would check the people who came and ask them to identify 'themselves. Th...