Jacobsen syndrome (JS), a rare disorder with multiple dysmorphic features, is caused by the terminal deletion of chromosome 11q. Short stature has been reported in this syndrome, however very few of these patients have undergone endocrine evaluation. Serum insulin-like growth factor-1 (IGF-1) levels are an indirect indicator of growth hormone activity and are a useful initial screening tool in ...

Recent studies have identified a (CCG)n repeat in the 5' untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B. It has also been demonstrated that FRA11B is the site of breakage in some cases of Jacobsen syndrome (JS) involving terminal deletions of chromosome 11q. We report on 2 ...

More than 70 patients with Jacobsen syndrome have been described [Penny et al., 1995; Pivnick et al., 1996; Ono et al., 1996]. The Jacobsen syndrome comprises mild to moderate psychomotor retardation, trigonocephaly, minor facial anomalies, cardiac defects, and thrombocytopenia. The syndrome is caused by distal deletions of chromosome arm 11q, including 11q24.1. Until now, no clear correlation ...

Robert B. Pratt*, Gretchen B. North, Anna L. Jacobsen, Frank W. Ewers and Stephen D. Davis Department of Biology, California State University, Bakersfield, Bakersfield, California 93311, USA; Department of Biology, Occidental College, Los Angeles, California 90041, USA; Biological Sciences Department, California State Polytechnic University, Pomona, California 91768, USA; and Natural Science Di...

Roger Falcone, Chris Jacobsen, Janos Kirz, Stefano Marchesini, David Shapiro, and John Spence Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Department of Physics, University of California, Berkeley, CA, USA Argonne National Laboratory,Argonne, IL, USA Northwestern University,Evanston, IL, USA NSLS II, Brookhaven National Laboratory, Upton, NY, USA Department of...

Catalytic aerobic dehydrogenation of organic substrates is going through a Renaissance. Recent advances in this area have led to the discovery of palladium-catalyzed alcohol dehydrogenations and oxidative heteroand carbocyclizations. The development of asymmetric catalytic dehydrogenations is the latest advance in a long line of catalytic asymmetric oxidation reactions. Introduction Asymmetric ...

Title: Suicidal intention, psychosocial factors and referral to further treatment-a one-year cross-sectional study of self-poisonings Authors: Mari A Bjornaas ([email protected]) Knut E Hovda ([email protected]) Fridtjof Heyerdahl ([email protected]) Karina Skog ([email protected]) Per Drottning ([email protected]) Anders Opdahl ([email protected]) Dag J...