The 2009 Annual Meeting of the International Pachyonychia Congenita Consortium (IPCC)* centered on the need to develop patient-friendly technologies to effectively and efficiently deliver nucleic acids to skin. The IPCC is a group of physicians and scientists who have agreed to work together to develop therapeutics for the rare skin disorder pachyonychia congenita (PC) (a list of IPCC members c...

Patch testing is a well-established method of diagnosing contact allergy wherein patients with a history and clinical picture of contact dermatitis are re-exposed to the suspected allergens under controlled conditions to verify the diagnosis [1]. The results of first innovative patch-testing technique were presented by the German dermatologist, Josef Jadassohn (1863-1936) in 1895. The safety an...

JADASSOHiN OF BRESLAU has been hailed as the originator of the patch-test (Jadassohn, 1896). But it is largely due to the work of Bonnevie (1939) in Copenhagen that the patch-test, particularly when exhibited in battery form, has come to hold its present important place in modern dermatology. Bonnevie also established a tradition for excellence in the technique of patch-testing throughout Scand...

Adnexal tumors (ATs) are primary skin tumors with benign or rarely, malignant behavior. They have been classified based on differentiation towards hair follicle, sebaceous, apocrine or eccrine gland. Few large-scale studies have focused on ATs. To determine the prevalence of ATs and to assess clinical and histopathological trend of ATs. A retrospective descriptive study of all ATs diagnosed in ...

A 38-year-old woman was examined because of an extensive nevus sebaceus of Jadassohn (NSJ) covering the right side of her scalp and her face. The lesion first became apparent on the crown of her scalp when she was 12 years old and then gradually extended to the occiput. By the age of 20 years, it appeared on the right side of her face. A partial excision was done on the right temple, but the le...

1. Paramyotonia congenita (PC) is a human hereditary disorder wherein missense mutations in the skeletal muscle sodium channel lead to cold-exacerbated muscle hyperexcitability. The most common site for PC mutations is the outermost arginine of domain i.v. segment 4 (human R1448, rat R1441). 2. We examined the rat homologues of two PC mutants with changes at this site: R1441P and R1441C. The R-...

Male mice emit ultrasonic vocalizations (USVs) towards females during male-female interaction. It has been reported that USVs of adult male mice have the capability of attracting females. Although the waveform pattern of USVs is affected by genetic background, differences among strains with respect to USV and the effects of these differences on courtship behavior have not been analyzed fully. W...

We report a six year old male with mental retardation, postaxial polydactyly and syndactyly, atrichia congenita totalis, severe seborrhoeic dermatitis, recurrent staphylococcal skin sepsis, and Perthes' disease of the hip. His birth may have resulted from an incestuous mating.