An imine-based approach was developed to prepare Janus gold nanoparticles (Janus AuNPs) having amine functionality on one patch of the surface and a polyethylene glycol unit on the other. This unique technique features covalent bonding as the force to immobilize AuNPs on the template, enabling direct modification of AuNPs in both water and organic solvents. Colloidal clusters were then obtained...

Janus gold nanoparticles are of high interest because they allow directed self-assembly and display plasmonic properties. We succeeded in coating gold nanoparticles with two different polymers that form a Janus shell. The spontaneous segregation of two immiscible polymers at the surface of the nanoparticles was verified by NOESY NMR and most importantly by electron microscopy analysis in two an...

Last lecture, we discussed Janus, which uses system call interposition to achieve software sandboxing isolation. We talked about a few problems that Janus had, particularly race conditions that can potentially allow malicious code to break software isolation property. Since then, a few more sandboxing projects have been implemented to address such issues. Today, we are going to look at a few re...

Janus particles, colloid-sized particles with two regions of different surface chemical composition, possess energetic interactions that depend not only on their separation but also on their orientation. Research on Janus and colloidal particles that are chemically patchy in even more complicated fashion has opened a new chapter in the colloid research field. This article highlights recent prog...

We designed a series of anilino-indoylmaleimides based on structural elements from literature JAK3 inhibitors 3 and 4, and our lead 5. These new compounds were tested as inhibitors of JAKs 1, 2 and 3 and TYK2 for therapeutic intervention in rheumatoid arthritis (RA). Our requirements, based on current scientific rationale for optimum efficacy against RA with reduced side effects, was for potent...

This paper argues that technologies perform in Janus faced ways; that is, in ways that are ironic, perverse and paradoxical, and it is argued that these qualities are important to apprehend if we are to more fully understand the role of technology in organizations and in our daily lives. The argument opens with an account of Janus as a metaphorical evocation of irony and paradox, and general ex...

We investigated the geometric and chemical factors of nonspherical Janus particles (i.e., Janus ellipsoids) with regard to the pinning and unpinning behaviors of the Janus boundary at the oil-water interface using attachment energy numerical calculations. The geometric factors were characterized by aspect ratio (AR) and location of the Janus boundary (α) separating the polar and apolar regions ...