OBJECTIVE To determine the clinical profile and therapeutic response of patients with juvenile dermatomyositis (JDM). DESIGN Hospital based descriptive follow-up study. SAMPLE 12 patients attending the Pediatric Rheumatology and Immunology Clinic over last five years. RESULTS The patients were aged between 3 1/2 years to 12 years with a male to female ratio of 2:1. All patients had proxim...

Objectives and study A 4year-old boy was admitted to our hospital because of progressive proximal muscular weakness of 4 weeks duration, heliotrope rash, erythematous skin lesions in the trunk and limbs and febrile fever. The muscle enzymes were elevated: creatine kinase 7,056 IU/L (0– 170), aldolase 40.3 U/L (0–8), aspartate transaminase 601 U/L (10–37), alanine transaminase 289 U/L (10–37). T...

Introduction An 8-year-old Iranian girl was referred because she had progressive muscle weakness predominantly in lower limbs since about 2 years ago. She was not able to stand from a sitting position without help and had difficulty climbing stairs. She walked slowly and could not run like before. She had no complaint of dysphagia or dysphonia. She was born through a normal vaginal delivery and...

Background Juvenile dermatomyositis (JDM) is characterised by chronic inflammation in skeletal muscle, skin, and other target organs. Prognosis has improved in the past 10-20 years, but it is still a disease with high morbidity and considerable sequelae such as muscle weakness, joint contractures, calcinosis and lipodystrophy. There is increasing evidence that single nucleotide polymorphisms (S...

Calcinosis cutis is a condition characterized by the deposition of calcium salts in the skin and subcutaneous tissues, and patients suffering from it encounter various connective tissue disorders, such as dermatomyositis (DM), scleroderma, and systemic lupus erythematosus. Although calcinosis cutis is frequently accompanied by juvenile dermatomyositis, rare cases have been reported in adult pat...

Idiopathic inflammatory myopathies (IIM) represent a group of autoimmune muscle conditions with variable organ involvement amongst the different types [1]. Juvenile dermatomyositis (JDM) is the most prevalent subgroup among children (accounting for up to 85% of cases), while polymyositis, inclusion body myositis and dermatomyositis are most common in adults [2]. JDM is primarily a capillary vas...