Nearly one million deaths are attributed to malaria every year. Recent reports of multi-drug treatment failure of falciparum malaria underscore the need to understand the molecular basis of drug resistance. Multiple mutations in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) are involved in chloroquine resistance, but the evolution of complex haplotypes is not yet well und...

To the Editor—We share the cogent sentiments expressed by Farcas et al. [1] about the great interest of PCR-based methods for the diagnosis of imported malaria, given that, in most westernized countries, morbidity and death due to this protozoan infection among returned travelers is on the rise [2]. Because we have tested 1900 patients per year since Octo-ber 1999, we have accumulated a large a...

Enweji, N. 2014. Dynamics of Resistant Plasmodium falciparum Parasites. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1020. 49 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9007-2. Persistence of drug resistant Plasmodium falciparum is a major problem to management and control malaria in endemic areas. The focus of this thesis was to study ...

Neutral mutations may hitchhike to high frequency when they are situated close to sites under positive selection, generating local reductions in genetic diversity. This process is thought to be an important determinant of levels of genomic variation in natural populations. The size of genome regions affected by genetic hitchhiking is expected to be dependent on the strength of selection, but th...

Acta Trop. 2009 Mar;109(3):245-6. Automated detection of haemozoin-containing monocytes for the diagnosis of malaria in microscopically negative cases during pregnancy. Hänscheid T, Längin M, Codices V, Luty AJ, Adegnika AA, Kremsner PG, Grobusch MP. Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon. Plasmodium falciparum sequesters in the placenta. Cell-Dyn automated flow cyt...