Kainate receptors (KARs) are heteromeric ionotropic glutamate receptors that play a variety of roles in the regulation of synaptic network activity. The function of glutamate receptors (GluRs) is highly dependent on their surface density in specific neuronal domains. Alternative splicing is known to regulate surface expression of GluR5 and GluR6 subunits. The KAR subunit GluR7 exists under diff...

Kainate-type glutamate receptors (KARs) are highly expressed in the developing brain, where they are tonically activated to modulate synaptic transmission, network excitability and synaptogenesis. NETO proteins are auxiliary subunits that regulate biophysical properties of KARs; however, their functions in the immature brain are not known. Here, we show that NETO1 guides the development of the ...

Hogyan lett egy három évvel ezelőtti álomból valóság? Számos konferenciát látogatva született meg koncepció annak kapcsán, hogy hozzunk létre olyan konferenciát, amely nem tudományterület köré épül, hanem több diszciplínát is felölel rendezvényen belül, ahol számos kutatás és jó gyakorlat felsorakoztathatja magát. A „határ a csillagos ég” prezentációk sokszínűségét tekintve, kritérium van csak,...

Abstract The intensification of the competitive environment between financial and credit institutions and the provision of new financial services in order to retain and attract customers, has made the use of more efficient electronic banking tools an inevitable necessity. Therefore, the present study intends to rank banks in terms of the efficiency of electronic services. In order to achi...

Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address their roles. With the development of selecti...

Kainate receptors (KARs) on CA1 pyramidal cells make no detectable contribution to EPSCs. We report that these receptors have a metabotropic function, as shown previously for CA1 interneurons. Brief kainate exposure caused long-lasting inhibition of a postspike potassium current (I(sAHP)) in CA1 pyramidal cells. The pharmacological profile was independent of AMPA receptors or the GluR5 subunit,...

Karyogamy is the process where haploid nuclei fuse to form a diploid nucleus during yeast mating. We devised a novel genetic screen that identified five new karyogamy (KAR) genes and three new cell fusion (FUS) genes. The kar mutants fell into two classes that represent distinct events in the yeast karyogamy pathway. Class I mutations blocked congression of the nuclei due to cytoplasmic microtu...