In any endeavor, there may be highs and lows and usually mixes. Strengths are needed and summoned in a way to assuage the difficulties. We have enjoyed an auspicious beginning. Volume 4 has enjoyed a good year, continuous exposure to international audiences, enthusiasm expressed by authors and observers and most importantly the publication of our first Supplement devoted to the Vinci Symposium ...

Looking Back, Moving Forward I am delighted to present the fourth issue of the ACG Case Reports Journal, which culminates our first year of publication. Over the past year, we received 470 submissions, of which 81 were selected for publication. Our success would not be possible without the efforts of the authors, reviewers, and editors, as well as ACG Publications Committee and ACG support staf...

Genetic ablation of inositol pyrophosphate synthesis has established the fundamental importance of this class of molecules to the eukaryote cell. These studies, however, must be complemented by cell biology and biochemical approaches to appreciate the signalling involved in the processes regulated by inositol pyrophosphates. A recent study by Chanduri et al. published in the Biochemical Journal...

evaluating, and expanding innovative strategies for HIV prevention and care. Horizons developed and tested ways to optimize HIV prevention, care, and treatment programs; worked to reduce stigma and improve gender-biased behaviors; and greatly expanded knowledge about the best ways to support, protect, and treat children affected by HIV and AIDS. In all its projects, Horizons strengthened the ca...

Kohl and Hootman are the outgoing Editors-in-Chief of the Journal of Physical Activity and Health, a role they have held since 2007. Kohl is with the Dept of Kinesiology and Health Education, University of Texas at Austin, and is the Founder and President of the International Society of Physical Activity and Health. Hootman is with the National Center for Chronic Disease Prevention and Health P...

Moving forward after YODA Bradley K. Weiner, MD*, Eric L. Hurwitz, DC, PhD, Mark L. Schoene, BS, Eugene J. Carragee, MD Department of Orthopedic Surgery, The Methodist Hospital, Houston, TX 77030, USA Office of Public Studies, University of Hawaii, Honolulu, HI 96822, USA The BackLetter, Philadelphia, PA 19103, USA Department of Orthopedic Surgery, Stanford University School of Medicine, 450 Br...