Orally disintegrating tablets are a solid dosage form compromising medicinal substances which disintegrate rapidly, generally within matter of seconds, when placed on the tongue. In this study, paracetamol orally was formulated and evaluated. Direct compression used to prepare 350 mg five formulations (F1- F5) by using single punch manual tableting machine. Pre-formulation studies were performe...

The episode (described in detail in accompanying article) depicted a man suffering potentially fatal liver damage after an untreated paracetamol overdose. Although the particular dose (50 tablets) and delay before presentation (2 days) were mentioned, the episode did not specify minimal toxic doses or maximum safe delays. At one week and 32 weeks after this episode was broadcast, we sent questi...

A simple yet sensitive high performance liquid chromatography method was developed and validated for the determination of paracetamol (PCM) content in different tablets dosage form. The mobile phase consisted of a mixture of methanol: water (80:20 v/v). The HPLC analysis was performed at a flow rate of 1 mL/min using a Thermo Synchronise C18 (150 × 4.6mm, 5μM) and an UV detection wavelength of ...

OBJECTIVE We aimed to evaluate the safety and efficacy of a fixed-dose combination (FDC) of tramadol and diclofenac versus a standard approved FDC of tramadol and paracetamol, in patients with acute moderate to severe pain. METHODS A total of 204 patients with moderate to severe pain due to acute musculoskeletal conditions (n=52), acute flare of osteoarthritis (n=52), acute flare of rheumatoi...

Polypharmacy, the concurrent use of multiple medications by one individual is a growing global issue driven by an ageing population and increasing prevalence of multi-morbidity[1]. Polypharmacy can be problematic: interactions between medications, reduced adherence to medication, burden of medication to patients, administration time, increased risk of errors and increased cost. Quality improvem...

PURPOSE To compare the duration of analgesia achieved following administration of buffered prilocaine versus plain prilocaine to patients undergoing surgical decompression of the median nerve. METHODS 40 (32 female and 8 male; mean age, 50.5 years) patients who underwent surgical decompression of carpal tunnel syndrome were recruited. Patients were randomly allocated to 2 groups: the alkalini...

In this paper, we report on the identification of batches of analgesic paracetamol (acetaminophen) tablets using nitrogen-14 nuclear quadrupole resonance spectroscopy ((14)N NQR). The high sensitivity of NQR to the electron charge distribution surrounding the quadrupolar nucleus enables the unique characterization of the crystal structure of the material. Two hypothesis were tested on batches o...

BACKGROUND Distalgesic, the prescription-only analgesic compound of paracetamol (325 mg) and dextropropoxyphene (32.5 mg) known as co-proxamol in the UK, was withdrawn from the Irish market as of January 2006. This study aimed to evaluate the impact of the withdrawal of distalgesic in terms of intentional drug overdose (IDO) presentations to hospital emergency departments (EDs) nationally. ME...

RP-HPLC; Chromatography; Hyoscine N-butyl bromide and paracetamol Abstract RP-HPLC chromatographic method was developed for the determination of hyoscine N-butyl bromide (HBB) and Paracetamol (PAR). In this chromatographic method, HBB and PAR were separated using C18 (25 cm · 4.6 mm i.d. 5 lm particle size) column as a stationary phase and water: methanol (50:50, V/V pH adjusted to 3.9 with CF3...