Cysteine cathepsins are a group of proteases involved in many physiological and pathological processes. Yet, the selective detection and inhibition of individual cathepsins is still challenging. This editorial is discussing the context of a recent work introducing a designed ankyrin repeat protein (DARPin) as novel approach for selective targeting of the protease cathepsin B.

As Editor of the Journal of Clinical Investigation, I am pleased to announce the January 2016 launch of JCI Insight, which will publish well-executed, high-quality research across biomedicine that presents a focused yet insightful line of investigation. The new journal, published under an open-access model, represents an expansion of the American Society for Clinical Investigation's longstandin...

In the October issue of Childhood Obesity, David Katz called for action on so-called ‘‘kid’’ food and proposed a day of national boycott to focus attention on this issue and bring about change. This roundtable brings together experts in policy, nutrition, and pediatrics to discuss the availability of kid food and the marketing of unhealthy food to children. The panel presents strategies and ide...

i Harriet Shezi Children’s Clinic, Chris Hani Baragwanath Hospital, Wits Paediatric HIV Clinics, University of the Witwatersrand ii Department of Molecular Medicine and Haematology, National Health Laboratory Service and Wits Paediatric HIV Clinics, University of the Witwatersrand iii Department of Paediatrics and Child Health, KID-CRU, Tygerberg Children’s Hospital & Stellenbosch University iv...