Mucinous tubular and spindle cell carcinoma (MTSCC) is a new tumorous entity which has been recently established. In this article, we examined the expression of neuroendocrine markers including neuron specific enolase (NSE), chromogranin A and synaptophysin in 16 cases of MTSCC using immunohistochemistry. The sex ratio (male: female) of the patients was 4:12. In normal kidney, distal tubules or...

Correlations were demonstrated among the growth rates, concentrations of kidney-type of phosphate-dependent gluta minase, and morphologies of seven types of transplanted and primary rat neoplasms. The exponential rates of growth in volume of each of the transplanted rat neoplasms were respec tively similar to their rates of cellular growth, measured with colchicine. The relative degrees of hist...

Electrolyte alterations and extra-renal disorders are quite frequent in patients undergoing haemodialysis or peritoneal dialysis. The native kidneys may be the site of important pathologies in patients undergoing dialysis, especially in the form of acquired renal cystic disease with frequent malignant transformation. Renal neoplasms represents an important complication of haemodialysis-associat...

background esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (git) neoplasms, causing almost two million deaths worldwide each year. some environmental risk factors are acknowledged; however, genetic defects can significantly contribute to predisposition to git cancers. accordingly, recent works have shown that single-nucleotide polymorphisms (snps) within m...

The combinations of genetic alterations that cooperate with von Hippel-Lindau (VHL) mutation to cause clear cell renal cell carcinoma (ccRCC) remain poorly understood. We show that the TP53 tumour suppressor gene is mutated in approximately 9% of human ccRCCs. Combined deletion of Vhl and Trp53 in primary mouse embryo fibroblasts causes proliferative dysregulation and high rates of aneuploidy. ...

The success of renal transplantation may be counterbalanced by serious adverse medical events. The effect of immunosuppression on the incidence of de novo neoplasms among kidney recipients should be monitored continuously. Using data from the Scientific Registry of Transplant Recipients, we studied the association of induction therapy by immunosuppression with antilymphocyte antibodies, with th...

The present work is undertaken to study the expression of levels of gelatinases in tumorogenesis by Rous sarcoma virus(RSV) in layer chicks and explored the possibility of using gelatinases as potential biological markers in metastatic neoplasms. Two days old chicks (40) were divided into two groups (Gp I and Gp II). Gp-I (20) treated with Rous sarcoma virus for tumor induction. The Gp II (cont...