The photodynamic effects of sc-terthienyl (scT) in near-UV light (UV-A) on Escherichiu coli showed close agreement with the light absorption of scT at different wavelengths suggesting that r T is the primary absorbing molecule responsible for the photosensitized reaction. Studies with DNA repair deficient mutants of E. coli indicated that the bactericidal action of otT/UV-A was not mediated by ...

This study aimed to investigate the cell-killing effect of HSV-tk/GCV suicide gene system driven by β-globin matrix attachment region (MAR) on ECA109 cells and its bystander effect. The integration and expression of lentivirus vectors HSV-tk and MAR-HSV-tk in ECA109 were identified using RT-PCR and Western blot; the cell survival rate and cell-killing bystander effect were detected in different...

Phagocytosis and mechanisms of killing of Aspergillus fumigatus conidia by murine alveolar macrophages (AM), which are the main phagocytic cells of the innate immunity of the lung, were investigated. Engulfment of conidia by murine AM lasts 2 h. Killing of A. fumigatus conidia by AM begins after 6 h of phagocytosis. Swelling of the conidia inside the AM is a prerequisite for killing of conidia....

Copper alloy surfaces are passive antimicrobial sanitizing agents that kill bacteria, fungi, and some viruses. Studies of the mechanism of contact killing in Escherichia coli implicate the membrane as the target, yet the specific component and underlying biochemistry remain unknown. This study explores the hypothesis that nonenzymatic peroxidation of membrane phospholipids is responsible for co...

The intracellular growth and susceptibilities to killing by H2O2 in cultured human monocytes of a number of mycobacterial species including laboratory strains and clinical isolates of Mycobacterium tuberculosis, and Mycobacterium bovis bacillus Calmette-Guerin (BCG) and a clinical isolate of Mycobacterium avium-M. intracellulare were examined. The clinical isolate of M. avium-M. intracellulare ...

The bleomycins are antitumor agents composed of various cationic amides of a common inactive bleomycinic acid. At 1 mug/ml at 37 degrees, the naturally occurring spermidine derivative of bleomycin (A5) was far more lethal to Escherichia coli than were several other bleomycins tested. An exponential loss of viability was produced for 2 hr in various strains of E. coli growing in a synthetic medi...

The HKM / HFX cryptosystem is proposed for standardization at the ITU Telecommunication Standardization Sector Study Group 8. It is designed to provide authenticity and colffidentiality of FAX messages at a commercial level of security. In addition, the HKM / HFX cryptosystem is designed for unrestricted export. This paper contains the results of an analysis of the HKM/HFX cryptosystem. Eleven ...

The in vitro susceptibility of group D streptococci (enterococci) to ampicillin was studied comparing the results obtained in Mueller-Hinton broth (MHB) with those obtained in normal human serum (NHS). The rate of enterococcal killing was consistently faster in NHS than in MHB at equivalent ampicillin concentrations. Whereas an increasing media pH appeared to decrease the susceptibility of ente...