diabetic retinopathy is the lead among causes of blindness in north america. glucose-induced endothelial injury is the most important cause of diabetic retinopathy and other vascular complications. extracellular signal-regulated kinase 5 (erk5), also known as big mitogen-activated protein kinase 1 (bmk1), is a member of mitogen-activated protein kinases (mapk) family. physiologically, it is cri...

Abstract Background Clear cell renal carcinoma (ccRCC), derived from tubular epithelial cells, is the most common malignant tumor of kidney. The study key genes related to pathogenesis ccRCC has become important for gene target therapy. Methods Bioinformatics analysis Cancer Genome Atlas (TCGA), NCBI Gene Expression Omnibus (GEO) database, USUC Xena cBioPortal Genomics, and MethSurv were perfor...