Germany officially the Federal Republic of Germany, is of the European conuntries. With 81.8 million inhabitants, it is the most populous member state in the European Union. It is one of the major political and economic powers of the European continent and a historic leader in many theoretical and technical fields [1]. The country has developed a very high standard of living and features a comp...

Kindler et al. (1956) reported that a strain of Clostridium parabotulinum type A synthesized large quantities of toxin in a medium where cell multiplication was inhibited by high concentrations of penicillin. This interpretation of synthesis de novo of protein was based on the observations that the toxicity of the extracellular fluids increased in the absence of cell multiplication. It is a wel...

In this paper, we prove an almost-optimal hardness for Max k-CSPR based on Khot’s Unique Games Conjecture (UGC). In Max k-CSPR, we are given a set of predicates each of which depends on exactly k variables. Each variable can take any value from 1, 2, . . . , R. The goal is to find an assignment to variables that maximizes the number of satisfied predicates. Assuming the Unique Games Conjecture,...

Background. Kindler epidermolysis bullosa is orphan, autosomal recessive disease and it one of the variants congenital bullosa. Its severe course characterized by high risk multifactorial malnutrition, chronic inflammation due to recurrent secondary skin infections, also bone metabolism disorders, what can lead disorders in physical development puberty children. However, effect on patients’ rem...