Objective: The objective of the present work was to formulate solid dispersions simvastatin for enhancement its aqueous solubility and dissolution rate.
 Methods: In study, were prepared by Kneading Solvent evaporation methods. polymeric carriers like Polyethylene glycol (PEG) 6000 Polyvinyl Pyrrolidone (PVP) K30 used in different ratios (ratio drug: carrier 1:1, 1:2) dispersions. characte...

Based on the mechanical test (shear test, compression test), bond model of corn kernel and straw was established to explore rolling crushing effect different rollers. The type roller is different. material process by force (extrusion kneading) analysis reveals that disc (DCR) has characteristics large unit-length kneading area; spiral-notched serrated (SNSCR) transverse shearing material; they ...

Purpose: The aim of this research was to formulate and develop an orally disintegrating tablet (ODT) that incorporated a MEL/β-CD complex, using a quality by design (QbD) approach to enhance solubility and drug release. Methods: Multiple regression linear analysis was conducted to develop the kneading process and ODT formulation. Mixing time and amount of solvent were used as independent variab...

(3) F (x+ 1) = F (x) + 1 for all x ∈ R. For a map F ∈ C and for each a ∈ Z we set F (a) = limx↓a F (x) and F (a) = limx↑a F (x). In view of (3) we have F (a ) = F (0) + a and F (a) = F (0) + a. Note that the exact value of F (0) is not specified. Then in what follows we consider that F (0) is either F (0) or F (0−), or both, as necessary. Since every map F ∈ C has a discontinuity in each intege...

We describe an interesting interplay between symbolic dynamics, the structure of the Mandelbrot set, permutations of periodic points achieved by analytic continuation, and Galois groups of certain polynomials. In the early 1990’s, Devaney asked the question: how can you tell where in the Mandelbrot set a given external ray lands, without having Adrien Douady at your side? We provide an answer t...