Neuritogenesis, the first step of neuronal differentiation, takes place as nascent neurites bud from the immediate postmitotic neuronal soma. Little is known about the mechanisms underlying the dramatic morphological changes that characterize this event. Here, we show that RhoA activity plays a decisive role during neuritogenesis of cultured hippocampal neurons by recruiting and activating its ...

Remodeling of epithelial sheets plays important roles in animal morphogenesis. Shroom3 is known to regulate the apical constriction of epithelial cells. Here, we show that Shroom3 binds ROCKs and recruits them to the epithelial apical junctions. We identified the Shroom3-binding site (RII-C1) on ROCKs, and found that RII-C1 could antagonize the Shroom3-ROCK interaction, interfering with the act...

Mechanical stress that arises due to deformation of the extracellular matrix (ECM) either stretches or compresses cells. The cellular response to stretching has been actively studied. For example, stretching induces phosphorylation of the myosin regulatory light chain (MRLC) via the RhoA/RhoA-associated protein kinase (ROCK) pathway, resulting in increased cellular tension. In contrast, the eff...

little is known about survival, longevity, dispersal, and social organisation of tree weta in the wild (Trewick and Morgan-Richards, 1995). Their relatively large size for an insect allows tree weta to be easily tagged. This, plus their flightlessness, potentially makes them ideal species for mark-recapture studies. The mountain stone weta, Hemideina maori (Pictet and Saussure), is unusual for ...

Both amidated gastrin (Gamide) and glycine-extended gastrin (Ggly) stimulate gastrointestinal cell proliferation and migration. Binding of Gamide to the cholecystokinin-2 receptor activates small GTP-binding proteins of the Rho family (Rho, Rac, and Cdc42), and dominant-negative mutants of Rho or Cdc42 block Gamide-stimulated cell proliferation and survival. In comparison, little is known about...

BACKGROUND Migrating leukocytes normally have a polarized morphology with an actin-rich lamellipodium at the front and a uropod at the rear. Microtubules (MTs) are required for persistent migration and chemotaxis, but how they affect cell polarity is not known. METHODOLOGY/PRINCIPAL FINDINGS Here we report that T cells treated with nocodazole to disrupt MTs are unable to form a stable uropod ...

1 A Case Study on Data Quality, Privacy, and Evaluating the Outcome of Entity Resolution Processes Pei Wang, University of Arkansas at Little Rock, Little Rock, AR, USA Daniel Pullen, University of Arkansas at Little Rock, Little Rock, AR, USA Fan Liu, University of Arkansas at Little Rock, Little Rock, AR, USA William C. Decker, University of Arkansas at Little Rock, Little Rock, AR, USA Ningn...

a r t i c l e i n f o The purpose of this study is to analytically predict and to experimentally investigate the seismic response of adjacent filled parallel rock fractures with dissimilar properties (e.g., fracture thickness and stiffness). The time-domain recursive method is extended to predict that a P-wave propagates normally across the filled parallel fractures using the specific stiffness...

Résumé : We consider challenging active diagnosis problems, that is, when smart exploration is needed to acquire information about a hidden target variable. Classical approaches rely on information-greedy strategies or ad-hoc algorithms for specific classes of problems. We propose to model this problem using the generic ρPOMDP formalism, which leads to an information-lookahead planning strategy...

This paper discusses a known-plaintext attack on a redundancy reducing cipher method which is proposed by Wayner. We also propose an extension of Wayner’s redundancy reducing cipher scheme so that the security will be improved greatly.