Oxidative stress may play an important role in the pathogenesis of keratoconus (KC). Mitochondrial DNA (mtDNA) is involved in mitochondrial function, and the mtDNA content, integrity, and transcript level may affect the generation of reactive oxygen species (ROS) and be involved in the pathogenesis of KC. We designed a case-control study to research the relationship between KC and mtDNA integri...

The murine chemokine CXCL1/KC is known as a chemoattractant for neutrophil infiltration and as a promoter of tumor growth. To determine its relevance in tumorigenesis, we first asked whether okadaic acid (OKA), a natural tumor promoter and a potent protein phosphatase 1 and 2A inhibitor, stimulates KC expression and if it does, through what pathway, in a promotable mouse epidermal-like JB6 cell...

Background: Mitochondrial DNA (mtDNA) variants have been implicated in keratoconus (KC). The present study aimed to characterize the mtDNA heteroplasmy profile KC and explore association of mitochondrial heteroplasmic levels with KC. Methods: sequencing peripheral blood samples corneal tomography were conducted 300 cases matched controls. number homoplasmic was calculated across genome. Spearma...

PURPOSE Current literature contains scant information regarding the extent of enzymatic collagen cross-linking in the keratoconus (KC) cornea. The aim of the present study was to examine levels of enzymatic lysyl oxidase-derived cross-links in stromal collagen in KC tissue, and to correlate the cross-link levels with collagen fibril stability as determined by thermal denaturation temperature (T...

Let R(Ka,b, Kc,d) be the minimum number n so that any n-vertex simple undirected graph G contains a Ka,b or its complement G′ contains a Kc,d. We demonstrate constructions showing that R(K2,b, K2,d) > b + d + 1 for d ≥ b ≥ 2. We establish lower bounds for R(Ka,b, Ka,b) and R(Ka,b, Kc,d) using probabilistic methods. We define R′(a, b, c) to be the minimum number n such that any n-vertex 3-unifor...

OBJECTIVE CC and CXC chemokines are implicated in leukocyte recruitment during development of atherosclerotic lesions, suggesting circulating levels of chemokines may be useful serum markers of atherogenesis. Serum chemokine concentrations were measured in apolipoprotein (apo) E*3 Leiden mice and their nontransgenic littermates and related to the differing rates of atherogenesis in these animal...

In this paper, we study the problem of activity detection (AD) in a massive MIMO setup, where the Base Station (BS) has M 1 antennas. We consider a flat fading channel model where the M -dim channel vector of each user remains almost constant over a coherence block (CB) containing Dc signal dimensions. We study a setting in which the number of potential users Kc assigned to a specific CB is muc...

Let C be a nonempty closed bounded convex subset of a Banach space X whose characteristic of noncompact convexity is less than 1 and T a continuous 1-χ-contractive SL map (which is not necessarily nonexpansive) from C to KC(X) satisfying an inwardness condition, where KC(X) is the family of all nonempty compact convex subsets of X . It is proved that T has a fixed point. Some fixed points resul...

Traylor ZP, Yu EN, Davis IC. Respiratory syncytial virus induces airway insensitivity to -agonists in BALB/c mice. Am J Physiol Lung Cell Mol Physiol 298: L437–L445, 2010. First published December 4, 2009; doi:10.1152/ajplung.00363.2009.— -Adrenergic agonists ( agonists) are commonly used to treat respiratory syncytial virus (RSV) bronchiolitis but are generally ineffective for unknown reasons....