BACKGROUND Human cathelicidin LL-37 is a cationic antimicrobial peptide (AMP) which possesses a variety of activities including the ability to neutralise endotoxin. In this study, we investigated the role of LPS neutralisation in mediating LL-37's ability to inhibit Pseudomonas aeruginosa LPS signalling in human monocytic cells. METHODOLOGY/PRINCIPAL FINDINGS Pre-treatment of monocytes with L...

We performed continuous and manual in situ measurements of CO2 efflux from the leaf litter layer (R(LL)) and water content of the leaf litter layer (LWC) in conjunction with measurements of soil respiration (RS) and soil water content (SWC) in a temperate forest; our objectives were to evaluate the response of R(LL) to rainfall events and to assess temporal variation in its contribution to R(S)...

A new parsing method called LLLR parsing is defined and a method for producing LLLR parsers is described. An LLLR parser uses an LL parser as its backbone and parses as much of its input string using LL parsing as possible. To resolve LL conflicts it triggers small embedded LR parsers. An embedded LR parser starts parsing the remaining input and once the LL conflict is resolved, the LR parser p...

n-phthaloyl gaba was administrated daily (50 mg/kg body weight-i.p) to wistar rats for 21 days and circadian rhythms of thiobarbituric acid reactive substances (tbars) and antioxidants such as reduced glutathione (gsh), catalase (cat) and superoxide dismutase (sod) were studied under constant light (ll) conditions. delayed acrophase of tbars and advanced acrophase of antioxidants (gsh, cat and ...

Dedicated to the memory of Moez Alimohamed Abstract We introduce a linear analogue of LL auchli's semantics for intuitionistic logic. In fact, our result is a strengthening of LL auchli's work to the level of proofs, rather than provability. This is obtained by considering continuous actions of the additive group of integers on a category of topological vector spaces. The semantics, based on fu...

STUDY QUESTION Does antimicrobial peptide, LL-37, inhibit sperm fertilizing ability? SUMMARY ANSWER Our results indicate that LL-37 inhibits mouse and human sperm fertilizing ability. WHAT IS KNOWN ALREADY LL-37, a cationic antimicrobial peptide, exerts its microbicidal effects through the disruption of microbial cytoplasmic membranes following its interaction with microbial surface anionic...

1 Department of Communication Sciences and Disordert Northwestern University. Evanston, lL, USA 2 Department of Radiology, Evanston Northwestern Healthcare, Evanston, llUSA 3 Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Medical School, Chicago, lL, USA 4 Department of Neurology, Northwestern University Medical School, Chicago, lL, USA s Department of Radiology. No...

The naturally occurring neurotoxin, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol; SAL), has been speculated to contribute to Parkinson's disease and neuropathology of chronic alcoholism. In the present study, we found the capability of SAL to cause DNA cleavage in the presence of Cu(ll). Incubation of SAL and CuCl2 with calf thymus DNA caused strand breaks. Likewise, SAL in...

The LL-D05139 complex, containing LL-D05139 beta and azaserine, was recovered from the fermentation filtrate of Glycomyces harbinensis (NRRL 15337). A chemically defined medium was developed which favored the production of LL-D05139 beta. Antibiotic LL-D05139 beta was isolated from the fermentation filtrate by adsorption on granular carbon and further purified by chromatography on microcrystall...