The present study was undertaken to define the effects of left ventricular hypertrophy on postischemic recovery of myocardial performance and high energy phosphate metabolism. Hemodynamics and 3`P-magnetic resonance spectra were monitored simultaneously in the isolated Langendorff-perfused rat heart during 30 minutes of ischemia and 30 minutes of reperfusion. Left ventricular hypertrophy was pr...

AIM To investigate the effect of increases in extracellular Ca(2+) entry produced by the L-type Ca(2+) channel agonist FPL-64176 (FPL) upon acute atrial arrhythmogenesis in intact Langendorff-perfused mouse hearts and its dependence upon diastolic Ca(2+) release from sarcoplasmic reticular Ca(2+) stores. METHODS Confocal microscope studies of Fluo-3 fluorescence in isolated atrial myocytes we...

Background: Myocardial contractile function has been studied extensively in isolated hearts using the Langendorff System. The effects of changing the heart rate on myocardial contractility have not been described. The aim of the present study was to examine the effects of changing the heart rate on studying myocardial contractility in isolated heart models using the Langendorff System, and to d...

In basic research using mouse heart, isolating viable individual cardiomyocytes is a crucial technical step to overcome. Traditionally, from rabbits, guinea pigs or rats has been performed via retrograde perfusion of the heart with enzymes Langendorff apparatus. However, high degree skill required when this method used small heart. An antegrade that does not use apparatus was recently reported ...

Myocardial ischaemia–reperfusion (I/R) injury is a well-known term for exacerbation of cellular destruction and dysfunction after the restoration blood flow to previously ischaemic heart. A vast number studies that have demonstrated role mineralocorticoids in cardiovascular diseases based on use pharmacological mineralocorticoid receptor (MR) antagonists. This review paper aimed summarize curre...