The presence of Langerhans cells in the developing mucosal epithelium of mice was investigated by ATPase histochemistry and by electron microscopy. In the stratified squamous epithelium of the tongue and forestomach, a few ATPase-positive Langerhans cells could be recognized at 1 or 2 weeks after birth. They increased in number by 3 weeks of age, but the density was lower than that in the epide...

BACKGROUND The hierarchical organization of hematopoiesis with unidirectional lineage determination has become a questionable tenet in view of the experimental evidence of reprogramming and transdifferentiation of lineage-determined cells. Clinical examples of hematopoietic lineage plasticity are rare. Here we report on a patient who presented with an acute B-lymphoblastic leukemia and develope...

BACKGROUND Langerhans cell histiocytosis is a rare systemic disease characterized by the abnormal overproduction of histiocytes that tend to infiltrate single or multiple organ systems leading to significant tissue damage. It mainly affects - by order of decreasing frequency - the bone, the skin, the lymph nodes, the liver, and lungs. Gastrointestinal tract involvement is extremely rare in adul...

Four neonates had solitary, congenital, rapidly growing, spontaneously ulcerating tumors of the face, trunk, and extremities. No extracutaneous involvement was found, and all lesions spontaneously involuted. Mononuclear cells of the cutaneous infiltrate were Langerhans' cells. These findings expand the spectrum of congenital self-healing reticulohistiocytosis. The Langerhans' cells (LC), dendri...

Langerhans' cell histiocytosis (LCH) is one of the 'histiocytosis disorders', as defined by the Histiocyte Society. LCH is an abnormal proliferation and dissemination of clonal Langerhans' cells in which they accumulate, along with other inflammatory cells, and form tissue granulomas in different organs. It is named after the appearance of the cells, which resemble the normal dendritic cells fo...

Langerhans cell histiocytosis is a rare disease of unknown cause, characterized by the proliferation of histiocytic cells (Langerhans cells), that can sometimes be especially difficult to diagnose due to its wide clinical spectrum, ranging from a single lesion to a multisystemic disorder. Appropriate disease staging is fundamental, since treatment depends upon the severity of the disease, and i...

Langerhans cell histiocytosis is characterized by abnormal accumulations of large mononuclear cells forming granulomas in various organs mainly in the lung, bone, or skin. Adult pulmonary Langerhans cell histiocytosis is rare and almost always associated with cigarette smoking; combination with lung and bone simultaneous involvement is even rare. We present a 41 years old male smoker who was di...

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease seen as part of multisystem Langerhans cell histiocytosis, or as an isolated form of the disease. The majority of cases of the latter are seen in adults and associated with cigarette smoking, which probably plays a central etiologic role. Although the mechanisms leading to the development of isolated PLCH are unc...

Introduction: Skin photoaging can be treated with ablative therapies that may cause immunological changes to the skin. Objective: To evaluate the results of chemabrasion in the treatment of perioral wrinkles and the change in number of Langerhans cells. Material e methods: Application of 35% trichloroacetic acid followed by manual dermabrasion using waterproof sandpaper in 12 female patients wi...

BACKGROUND Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by the HISTSOC-LCH-III (NCT00276757) trial show an improvement in the survival of children with langerhans cell histiocytosis. CASE PRESENTATION We report a case of Langerhans cel...