PURPOSE To report a specific line of research developed at the University of São Paulo/Brazil on fibrin glue used for sealing corneal perforations and the perspectives of use on non-perforated corneal ulcers and photorefractive keratectomy-operated corneas. METHODS To describe fibrin glue manufacture, development of a device to test the glued perforated corneal area resistance, subsequent exp...

Purpose To compare visual outcomes and satisfaction among patients of photorefractive keratectomy (PRK; Wavelight EX 500, Alcon, Ft Worth, TX, USA) and femtosecond laser-assisted in situ keratomileusis (FAL; Wavelight FS 200 laser and Wavelight EX 500, Alcon, Ft Worth, TX, USA). Methods We performed a retrospective study of 409 eyes in 207 patients that underwent either PRK (n=90) or FAL (n=117...

An indirect immunohistochemical technique was used to monitor the expression of cellular fibronectin (cFN) and tenascin (TN) in the rabbit cornea after photorefractive keratectomy (PRK) in a 1 year follow up study. Rabbits received a 5.0 D myopic PRK, and were killed 3 days, 1, 3, 6, or 12 months after the operation. In most corneas, secondary epithelial defects appeared after the primary heali...

BACKGROUND Although there have been many studies of the efficacy and safety of wavefront- guided (WF) and cross-cylinder photorefractive keratectomy (PRK), there are few studies on moderate-to-high astigmatism cases. The aim of this study was to assess and compare the efficacy of WF and cross-cylinder PRK in moderate-to-high astigmatism. METHODS In a comparative cohort, the results of two bef...

We read with great interest the article by Aghazadeh Amiri et al. concerning the corneal thickness (CT) measurements with Scheimpflug and slit scanning imaging techniques in keratoconus (KC). We would like to congratulate with the authors for their very interesting paper because it is well known that the measurement of CT is involved in the reliability of intraocular pressure measurements, both...

PURPOSE To compare the outcomes and complications of alcohol-assisted versus mechanical corneal epithelial debridement for photorefractive keratectomy (PRK). METHODS This randomized controlled trial included 1,250 eyes of 625 patients undergoing PRK for correction of myopia and myopic astigmatism. Each patient was randomly assigned to alcohol-assisted or mechanical epithelial removal. RESUL...

PURPOSE To evaluate the safety and efficacy of intrastromal corneal ring segments (ICRS) implantation followed by same-day topography-guided photorefractive keratectomy (PRK) and ultraviolet-A/riboflavin collagen cross-linking (CXL) in patients with low to moderate keratoconus. METHODS Patients with low to moderate keratoconus and contact lens intolerance were included in the study. All patie...

BACKGROUND The aim of this study was to evaluate long-term efficacy, safety, stability, and predictability of photorefractive keratectomy (PRK) as treatment of astigmatism. MATERIAL/METHODS Ninety-four eyes of 52 patients, treated with PRK for compound myopic astigmatism, compound hyperopic astigmatism, and mixed astigmatism were studied during a 36-month period. Main outcome measures were un...

Photorefractive keratectomy (PRK) represents a therapeutic option to remodel corneal stroma and to compensate refractive errors, which involves inflammatory and/or regenerative processes. In this context, the modulation of cytokines/chemokines in the conjunctival sac fluid and their role in the maintenance of the corneal microenvironment during the healing process upon refractive procedures has...

Purpose. To assess near visual acuity in a presbyopic age group following hyperopic photorefractive keratectomy (PRK). Setting. Private practice in Siena, Italy. Methods. In this retrospective single-surgeon comparative study, PRK with mitomycin C was performed to correct hyperopia using Bausch & Lomb 217z laser for 120 eyes of 60 patients in the presbyopic age group (mean spherical equivalent ...