AIMS Recent studies have shown that several genetic variants near the PITX2 locus on chromosome 4q25 are associated with atrial fibrillation (AF). However, the mechanism that mediates this association remains unclear. Basic murine studies suggest that reduced PITX2 expression is associated with left atrial dilatation. We sought to examine the association between single nucleotide polymorphisms ...

Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers. All 50 household contacts, including three spouses of LAV antibody-positive adult hemophiliacs, were ...

The information and recommendations contained in this document were developed and compiled by CDC in consultation with individuals appointed by their organizations to represent the Conference of State and Territorial Epidemiologists, the Association of State and Territo­ rial Health Officers, the National Association of County Health Officers, the Division of Mater­ nal and Child Health (Health...

BACKGROUND Interventional closure of the left atrial appendage (LAA) in patients with non-valvular atrial fibrillation, high thromboembolic and bleeding risk or bleeding history is an alternative therapeutic strategy to oral anticoagulation. It is not known if the exclusion of the LAA from the blood circulation affects the left atrial volume (LAV) and consequently its prognostic value or the ci...

are expensive, potentially dangerous, and current guidelines recommend their use in IPAH, but not in PH-HFpEF, where they are harmful (2). In HFpEF, there is preserved LV systolic function, but impaired diastolic function with abnormal LV relaxation and increased LV filling pressure. Sustained elevations of LV diastolic filling pressures will result in enlargement of the thin-walled left atrium...

The complete 9193-nucleotide sequence of the probable causative agent of AIDS, lymphadenopathy-associated virus (LAV), has been determined. The deduced genetic structure is unique: it shows, in addition to the retroviral gag, pol, and env genes, two novel open reading frames we call Q and F. Remarkably, Q is located between pol and env and F is half-encoded by the U3 element of the LTR. These d...

Abstract Funding Acknowledgements Type of funding sources: None. Background Left atrial enlargement (LAE) is a risk factor for fibrillation, stroke and heart failure with preserved ejection fraction. Current ASE/EACVI guidelines recommend indexing left volume (LAV) by body surface area (BSA) LAE grading. However, in overweight patients, this ratio must be interpreted caution due to disproportio...