PURPOSE: We studied the effects of exposure to mitomycin C and 5-Fluorcuracil to human RPE cultures, in growth inhibition and citoxicity. METHODS: 1) Growth inhibition: RPE cultures (3.000 cells/well) were exposed to different concentrations of mitomycin C and 5-Fluorouracil, and cell viability (MTT test) was evaluated 48h, 72h and 96h after. 2) Citotoxicity: RPE cultures (10.000 cells/well) we...

The estuarine planktonic copepods have a wide geographical distribution and commendable tolerance to various kinds of contaminants. The primary aim of the present study was to contrast the impacts of model POPs (TBBPA and HBCD) on three common estuarine planktonic copepods (Oithona similis, Acartia pacifica and Pseudodiaptomus inopinus) and establish a protocol for the assessment of acute toxic...

Ionic status during early development was investigated in the purple sea urchin. Whole body cation concentrations (Ca(2+), Na(+), K(+), Mg(2+)), unidirectional Ca(2+) uptake rates measured with (45)Ca(2+), Ca(2+)-ATPase activity, and growth were examined at 12h intervals over the first 96h of development. Whole body Ca(2+) concentration was low initially but increased steadily by >15-fold throu...

In this study, the lethal toxicity, behavioral responses and hematotoxicity of formulated chlorpyrifos on Clarias gariepinus was evaluated. C. gariepinus fingerlings were exposed to 0.2 mg/L, 0.25 mg/L, 0.3 mg/L, 0.35 mg/L and 0.4 mg/L of the active ingredient chlorpyrifos to determine the lethal concentrations and behavioral effects. C. gariepinus juveniles (38.84±7.67g) were then exposed to 0...

In this study, the lethal toxicity, behavioral responses and hematotoxicity of formulated chlorpyrifos on Clarias gariepinus was evaluated. C. gariepinus fingerlings were exposed to 0.2 mg/L, 0.25 mg/L, 0.3 mg/L, 0.35 mg/L and 0.4 mg/L of the active ingredient chlorpyrifos to determine the lethal concentrations and behavioral effects. C. gariepinus juveniles (38.84±7.67g) were then exposed to 0...

background: the presence of pesticides is very prevalent in surface waters of iran. these toxic substances may accumulate in the food chain and cause serious ecological and health problems. the aim of this study was to determine the acute toxicity of glyphosate, deltamethrin and pretilachlor as potential dangerous organic pesticides to assess lethal effects of these chemicals agents to the gupp...

PURPOSE: We studied the effects of exposure to mitomycin C and 5-Fluorcuracil to human RPE cultures, in growth inhibition and citoxicity. METHODS: 1) Growth inhibition: RPE cultures (3.000 cells/well) were exposed to different concentrations of mitomycin C and 5-Fluorouracil, and cell viability (MTT test) was evaluated 48h, 72h and 96h after. 2) Citotoxicity: RPE cultures (10.000 cells/well) we...

Atrazine is currently the most widely used herbicide in agriculture for the production of corn and other crops in the world. In the present research, the effect of acute and chronic toxicity of atrazine (herbicide) on blood biochemical indices of grass carp (Ctenopharhyngoden idella) an important species of commercial fish was studied. In acute toxicity, pollutant toxicity to fish was tested by...