Smoking is a established cardiovascular disease risk factor. But the mechanism how i t causes cardiovascular risk is still not properly understood. This study was aimed to evaluate effects of smoking on lecithin:cholesterol acyltransferase (LCAT) activity ,a key factor in the esterification of plasma cholesterol and reverse cholesterol transport. 30 male cigarette smokers and 30 male non-smoker...

BACKGROUND Prospective epidemiological studies have shown that low plasma levels of HDL cholesterol (HDL-C) are associated with an increased risk for cardiovascular disease (CVD). Despite nearly 40 years of research, however, it is unclear whether this also holds true for individuals with severely reduced levels of HDL-C due to mutations in the lecithin:cholesterol acyltransferase (LCAT) gene. ...

We investigate the utility of infrared fundus examination in a case of lecithin cholesterol acyltransferase (LCAT) deficiency. A 57-year-old woman presented with blurred vision in both eyes. Her eyes had been grayish blue since a young age. She was diagnosed as LCAT deficiency at the age of 50. Slit-lamp examination revealed diffuse bilateral opacity of the corneal stroma. Because of the hazy v...

Clinical and biochemical manifestations of lecithin-cholesterol acyltransferase (LCAT) deficiency include an abnormal lipid profile (characterized by hypercholesterolemia with markedly decreased high-density lipoprotein cholesterol [HDL-C] and hypertriglyceridemia), corneal opacities, hematologic abnormalities (normochromic anemia of varying intensity), splenomegaly, variable early coronary art...

Lecithin:cholesterol acyltransferase (LCAT; phosphatidylcholine-sterol acyltransferase, EC 2.3.1.43) is a glycoprotein which is responsible for the formation of cholesteryl ester in plasma. The carbohydrate content has been estimated to be approx. 25% of the total LCAT mass, and four potential N-linked glycosylation sites have been predicted at residues 20, 84, 272 and 384 of the LCAT protein s...

Cholesterol oxides are atherogenic and can affect the activity of diverse important enzymes for the lipidic metabolism. The effect of 7b-hydroxycholesterol, 7-ketocholesterol, 25-hydroxycholesterol, cholestan-3b,5a,6b-triol,5,6b-epoxycholesterol, 5,6a-epoxycholesterol and 7a-hydroxycholesterol on esterification of cholesterol by lecithin:cholesterol acyl transferase (LCAT, EC 2.3.1.43) and the ...

Complete lecithin cholesterol acyltransferase (LCAT) deficiency uniformly results in a profound HDL deficiency. We recently reported unexpected enhanced insulin sensitivity in LCAT knock-out mice in the LDL receptor knock-out background (Ldlr(-/-)×Lcat(-/-); double knock-out (DKO)), when compared with their Ldlr(-/-)×Lcat(+/+) (single knock-out (SKO)) controls. Here, we report that LCAT-deficie...

The objective of this pilot study was to examine the usefulness of limbal autograft transplantation (LCAT) in the treatment of recurrent pterygium. Eleven eyes with advanced recurrent pterygium underwent LCAT. All eyes were previously treated at least two times either by simple excision (10) or conjunctival rotation autograft (1). In two eyes (18.18%) symblepharon was present at the time of sur...