Previous studies on tau protein showed that the protein forms paracrystals which are unusually elastic. The paracrystals were obtained from a mixture of isoforms prepared from brain tissue, and the protein was in a mixed state of phosphorylation. Subsequently we showed that the structure and elasticity was related to the state of phosphorylation. However, this left open the possibility that the...

AIMS To evaluate the effect of considerably high left ventricular filling pressure with mitral regurgitation on mitral annular velocity during early diastole. SUBJECTS Two hundred and forty-three patients who underwent cardiac catheterization for evaluation of chest pain. METHODS Mitral annular velocity during early diastole was measured by colour M-mode tissue Doppler imaging. Patients wer...

INTRODUCTION In Alzheimer's disease (AD), accelerated neurofibrillary tangle formation occurs which is associated with increased tau protein release into the cerebrospinal fluid (CSF). Recent studies found significantly increased CSF tau already in patients at risk of developing AD, indicating its potential as a biochemical marker of AD. Cerebral glucose metabolism is reduced in frontotemporopa...

OBJECTIVES The aim of this study was to assess the effects of ischemia on diastolic function by analyzing flow propagation velocity with color M-mode Doppler echocardigraphy. BACKGROUND Color M-mode Doppler echocardiography has been proposed as a method of assessing left ventricular filling. METHODS Color M-mode Doppler echocardiography and measurement of hemodynamic data were performed sim...

Background Braak’s model of Alzheimer’s disease (AD) progression suggests that the initial accumulation hyperphosphorylated tau protein is seen in locus coeruleus (LC). Tau pathology might be a good marker subsequent cognitive decline initially unimpaired participants. We capitalized on to assess sample cognitively late-middle-aged individuals, relationship between and Aß cœruleus, basal forebr...

The endothelin (ET) system is involved in the regulation of myocardial function in health as well as in several diseases, such as congestive heart failure, myocardial infarction, and septic myocardial depression. Conflicting results have been reported regarding the acute contractile properties of ET-1. We therefore investigated the effects of intracoronary infusions of ET-1 and of the selective...

BACKGROUND Sepsis can be complicated by severe myocardial dysfunction and is associated with increased nitric oxide (NO) production by inducible NO synthase (NOS2). To investigate the role of NOS2 in endotoxin-induced myocardial dysfunction in vivo, we studied wild-type and NOS2-deficient mice. METHODS AND RESULTS Serial echocardiographic parameters of myocardial function were measured before...

Precision measurements of the anomalous electromagnetic moment leptons ( a l ) may serve as one most promising directions in search for new physics beyond Standard Model. While experimental value electron magnetic agrees with theoretical predictions up to 11 significant digits, muon shows deviations from Model at level 4.2 sigma, indicating possible occurrence effects. Although τ tau lepton its...

The objective of this study was to evaluate the effect of muscarinic receptor modulation on basal and beta-adrenergic stimulated left ventricular function in patients with heart failure. 21 heart failure patients and 14 subjects with normal ventricular function were studied. In Protocol 1 intracoronary acetylcholine resulted in a 60+/-8% inhibition of the left ventricular +dP/dt response to int...

Experimental measurements collected by the BABAR, Belle, and LHCb experiments on different observables associated with semileptonic transition $b \to c \tau \bar{\nu}_\tau$, indicate existence of disagreement respect Standard Model predictions. We analyse charged scalar boson contributions to these charged-current $B$ meson anomalies within framework two Higgs doublet model most general Yukawa ...